The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission

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dc.contributor.authorDonoso, Veronica
dc.contributor.authorGomez, Christian R.
dc.contributor.authorOrriantia, Miguel Angel
dc.contributor.authorPerez, Viviana
dc.contributor.authorTorres, Claudio
dc.contributor.authorCoddou, Claudio
dc.contributor.authorNelson, Pablo
dc.contributor.authorMaisey, Kevin
dc.contributor.authorMorales, Bernardo
dc.contributor.authorFernandez, Ricardo
dc.contributor.authorImarai, Monica
dc.contributor.authorHuidobro Toro, Juan Pablo
dc.contributor.authorSierra, Felipe
dc.contributor.authorAcuna Castillo, Claudio
dc.date.accessioned2024-01-10T12:09:52Z
dc.date.available2024-01-10T12:09:52Z
dc.date.issued2008
dc.description.abstractAging results in a general decline in the response to external insults, including acute inflammatory challenges. In young animals, the inflammatory response requires activation of the sympathetic system, including neurotransmitters Such as ATP, and catecholamines (epinephrine and norepinephrine). To test whether aging affects activation of this axis, and whether this in turn might affect cytokine release, we administered lipopolysaccharide (LPS) i.p. to adult, middle-aged and aged Fisher 344 rats (6-, 15- and 23-month old, respectively) and evaluated the early (0-12 h) serum levels of Neuropeptide-Y (NP-Y), ATP and vanillyl mandelic acid (VMA, as in indirect measurement of catecholamine levels). In addition, we evaluated the association between these factors and serum levels of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-10 (IL-10). Induction of both ATP and NP-Y was markedly reduced in the serum of aged animals, when compared to their younger Counterparts, while induction of VMA was not affected by age. in spite of these changes, serum levels of TNF alpha and IL-10 were strongly hyper induced and delayed in aged rats. The results suggest that during aging there is a dys-regulation in sympathetic neurotransmitter regulatory Mechanisms, and this might play a role in the impairment of the inflammatory response. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
dc.description.funderBicentenario para la Insercion de Jovenes Investigadores a la Academia
dc.description.funderFONDECYT
dc.description.funderDICYT
dc.description.funderFONDAP
dc.description.funderMIFAB
dc.description.funderNIH/NIA
dc.description.funderAG13902
dc.description.funderNATIONAL INSTITUTE ON AGING
dc.fechaingreso.objetodigital01-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.mad.2008.09.018
dc.identifier.issn0047-6374
dc.identifier.pubmedidMEDLINE:18973771
dc.identifier.urihttps://doi.org/10.1016/j.mad.2008.09.018
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76529
dc.identifier.wosidWOS:000262809200006
dc.information.autorucCiencias Biológicas;Coddou C;S/I;9297
dc.information.autorucCiencias Biológicas;Donoso V;S/I;100241
dc.information.autorucCiencias Biológicas;Huidobro-Toro J;S/I;98862
dc.information.autorucCiencias Biológicas;Imarai M;S/I;68057
dc.information.autorucCiencias Biológicas;Nelson P;S/I;101687
dc.issue.numero12
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final734
dc.pagina.inicio728
dc.publisherELSEVIER IRELAND LTD
dc.revistaMECHANISMS OF AGEING AND DEVELOPMENT
dc.rightsacceso restringido
dc.subjectSympathetic neurotransmitter
dc.subjectInflammation
dc.subjectCytokines
dc.subjectAging
dc.subjectTUMOR-NECROSIS-FACTOR
dc.subjectIMMUNE-SYSTEM
dc.subjectNEUROPEPTIDE-Y
dc.subjectMICE
dc.subjectNOREPINEPHRINE
dc.subjectRECEPTORS
dc.subjectPATHOPHYSIOLOGY
dc.subjectCATECHOLAMINES
dc.subjectMODULATION
dc.subjectPHYSIOLOGY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission
dc.typeartículo
dc.volumen129
sipa.codpersvinculados9297
sipa.codpersvinculados100241
sipa.codpersvinculados98862
sipa.codpersvinculados68057
sipa.codpersvinculados101687
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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