Adaptive regulation of hepatic bile salt transport: Role of bile salt hydrophobicity and microtubule-dependent vesicular pathway

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dc.contributor.authorArrese, M
dc.contributor.authorPizarro, M
dc.contributor.authorSolis, N
dc.contributor.authorAccatino, L
dc.date.accessioned2024-01-10T12:37:25Z
dc.date.available2024-01-10T12:37:25Z
dc.date.issued1997
dc.description.abstractBackground/Aims: The hepatic transport of bile salts can be regulated by changes in bile salt pool size and/ or in the flux of bile salts through the liver, Prolonged bile salt pool depletion is associated with down-regulation of maximum taurocholate transport and decreased canalicular membrane specific bile salt binding sites, This study was undertaken to investigate: a) whether adaptive down-regulation of maximum hepatic bile salt transport occurs to the same extent for bile acids of different hydrophobicity; and b) the role of microtubule-dependent vesicular pathway in the adaptive changes of bile salt transport capacity.
dc.description.abstractMethods: Male rats were subjected to 24-h or 48-h external biliary diversion to induce bile salt pool depletion, Basal bile how, bile salt secretion and lipid secretion, maximum secretory rate of three bile salts of different hydrophobicity (tauroursodeoxycholate, taurocholate and taurochenodeoxycholate) and changes in the biliary excretion of two markers of the microtubule-dependent vesicular pathway (horseradish peroxidase and polyethyleneglycol molecular weight-900) were measured in control and bile salt-depleted rats, Taurocholate-stimulated horse-radish peroxidase biliary excretion was also assessed in order to define whether the restoration of bile salt flux across the hepatocytes increased the excretion of this marker in bile salt-depleted rats,
dc.description.abstractResults: The reduction in the maximum secretory rate of the three bile salts under study observed after prolonged biliary diversion was clearly related to their hydrophobicity, with greater reduction for taurochenodeoxycholate and smaller reduction for tauroursodeoxycholate, compared with taurocholate, The biliary excretion of vesicular transport markers was significantly reduced in bile salt-depleted rats, However, when stimulated by taurocholate, biliary excretion of horseradish peroxidase was similar to controls.
dc.description.abstractConclusions: The magnitude of the decrease of the hepatic bile salt maximum transport capacity seen after bile salt pool depletion is directly related to the hydrophobicity of the bile salt infused, A functionally depressed vesicular transport pathway appears to be also a contributing factor to this phenomenon.
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0168-8278(97)80437-0
dc.identifier.issn0168-8278
dc.identifier.pubmedidMEDLINE:9075679
dc.identifier.urihttps://doi.org/10.1016/S0168-8278(97)80437-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76841
dc.identifier.wosidWOS:A1997XB66700031
dc.information.autorucMedicina;Accatino L;S/I;99016
dc.information.autorucMedicina;Arrese M;S/I;76095
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final702
dc.pagina.inicio694
dc.publisherMUNKSGAARD INT PUBL LTD
dc.revistaJOURNAL OF HEPATOLOGY
dc.rightsacceso restringido
dc.subjectadaptation
dc.subjectbile salts
dc.subjectdown-regulation
dc.subjecthepatic transport
dc.subjecthorseradish peroxidase
dc.subjecthydrophobicity
dc.subjectvesicular transport
dc.subjectMAXIMUM SECRETORY RATE
dc.subjectBILIARY-EXCRETION
dc.subjectHORSERADISH-PEROXIDASE
dc.subjectHEPATOCYTE COUPLETS
dc.subjectCHOLIC-ACID
dc.subjectLIVER
dc.subjectCHOLESTASIS
dc.subjectCHOLESTEROL
dc.subjectDAMAGE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdaptive regulation of hepatic bile salt transport: Role of bile salt hydrophobicity and microtubule-dependent vesicular pathway
dc.typeartículo
dc.volumen26
sipa.codpersvinculados99016
sipa.codpersvinculados76095
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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