MR Fingerprinting for Liver Tissue Characterization: A Histopathologic Correlation Study

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dc.contributor.authorFujita, Shohei
dc.contributor.authorSano, Katsuhiro
dc.contributor.authorCruz, Gastao
dc.contributor.authorFukumura, Yuki
dc.contributor.authorKawasaki, Hideo
dc.contributor.authorFukunaga, Issei
dc.contributor.authorMorita, Yuichi
dc.contributor.authorYoneyama, Masami
dc.contributor.authorKamagata, Koji
dc.contributor.authorAbe, Osamu
dc.contributor.authorIkejima, Kenichi
dc.contributor.authorBotnar, Rene M.
dc.contributor.authorPrieto, Claudia
dc.contributor.authorAoki, Shigeki
dc.date.accessioned2025-01-20T20:18:14Z
dc.date.available2025-01-20T20:18:14Z
dc.date.issued2023
dc.description.abstractBackground: Liver MR fingerprinting (MRF) enables simultaneous quantification of T1, T2, T2*, and proton density fat fraction (PDFF) maps in single breath-hold acquisitions. Histopathologic correlation studies are desired for its clinical use.Purpose: To compare liver MRF-derived metrics with separate reference quantitative MRI in participants with diffuse liver disease, evaluate scan-rescan repeatability of liver MRF, and validate MRF-derived measurements for histologic grading of liver biopsies. Materials and Methods: This prospective study included participants with diffuse liver disease undergoing MRI from July 2021 to January 2022. Participants underwent two-dimensional single-section liver MRF and separate reference quantitative MRI. Linear regression, Bland-Altman plots, and coefficients of variation were used to assess the bias and repeatability of liver MRF measurements. For participants undergoing liver biopsy, the association between mapping and histologic grading was evaluated by using the Spearman correlation coefficient.Results: Fifty-six participants (mean age, 59 years +/- 15 [SD]; 32 women) were included to compare mapping techniques and 23 participants were evaluated with liver biopsy (mean age, 52.7 years +/- 12.7; 14 women). The linearity of MRF with reference measurements in participants with diffuse liver disease (R2 value) for T1, T2, T2*, and PDFF maps was 0.86, 0.88, 0.54, and 0.99, respectively. The overall coefficients of variation for repeatability in the liver were 3.2%, 5.5%, 7.1%, and 4.6% for T1, T2, T2*, and PDFF maps, respectively. MRF-derived metrics showed high diagnostic performance in differentiating moderate or severe changes from mild or no changes (area under the receiver operating characteristic curve for fibrosis, inflammation, steatosis, and siderosis: 0.62 [95% CI: 0.52, 0.62], 0.92 [95% CI: 0.88, 0.92], 0.97 [95% CI: 0.96, 0.97], and 0.74 [95% CI: 0.57, 0.74], respectively).Conclusion: Liver MR fingerprinting provided repeatable T1, T2, T2*, and proton density fat fraction maps in high agreement with reference quantitative mapping and may correlate with pathologic grades in participants with diffuse liver disease.(c) RSNA, 2022
dc.fuente.origenWOS
dc.identifier.doi10.1148/radiol.220736
dc.identifier.issn0033-8419
dc.identifier.urihttps://doi.org/10.1148/radiol.220736
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92449
dc.identifier.wosidWOS:000907159600033
dc.issue.numero1
dc.language.isoen
dc.pagina.final159
dc.pagina.inicio150
dc.revistaRadiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMR Fingerprinting for Liver Tissue Characterization: A Histopathologic Correlation Study
dc.typeartículo
dc.volumen306
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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