Stereological Quantification of Extraocular Muscles in Humans

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dc.contributor.authorSan-Martin, J.
dc.contributor.authorLuna, C.
dc.contributor.authorGarreton, R.
dc.contributor.authorAraneda, S.
dc.contributor.authorSalgado, C.
dc.contributor.authorRodriguez, A.
dc.contributor.authorSalgado, G.
dc.date.accessioned2025-01-20T22:22:19Z
dc.date.available2025-01-20T22:22:19Z
dc.date.issued2021
dc.description.abstractThe aim of this study is to quantify muscular and connective tissue volumes of extraocular muscles (EOM) in humans with no ophthalmological disease using stereology. EOM from five cadaveric non-strabismic humans were obtained. The number of muscle fibers in 5,000 mu m(2) and volume density (Vv) of muscle and collagen were measured using stereology. Comparisons between antagonist EOM were conducted using Wilcoxon signed rank test for paired samples. A secondary analysis examining differences between pairs of EOM was also conducted. Bilateral tests were performed, and significance was set at 0.05. The horizontal rectus muscles (medial and lateral rectus) had the highest Vv of muscle and the lowest Vv of collagen. The inferior rectus muscle tended to have a fewer number of fibers per 5,000 mu m(2) than the rest of the EOM. However, these differences did not reach statistical significance. This is the first published study describing the normal histology of human EOM using stereology. Our investigation, through the quantification of the proportion of muscle and collagen tissue, as well as the number of muscle fibers in 5,000 mu(2), establishes normal stereological parameters for EOM of humans without ophthalmological disease.
dc.fuente.origenWOS
dc.identifier.eissn0717-9367
dc.identifier.issn0717-9502
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94674
dc.identifier.wosidWOS:000644964900025
dc.issue.numero2
dc.language.isoen
dc.pagina.final511
dc.pagina.inicio506
dc.revistaInternational journal of morphology
dc.rightsacceso restringido
dc.subjectOculomotor muscles
dc.subjectHumans
dc.subjectHistology
dc.subjectAnatomy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStereological Quantification of Extraocular Muscles in Humans
dc.typeartículo
dc.volumen39
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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