Towards chlorocytes for therapeutic intravascular photosynthesis

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dc.article.number489
dc.catalogadoraba
dc.contributor.authorVargas Torres Valentina Isabel
dc.contributor.authorBecerra, Daniela
dc.contributor.authorBoric P., Mauricio
dc.contributor.authorEgaña, José T.
dc.date.accessioned2025-04-01T15:31:24Z
dc.date.available2025-04-01T15:31:24Z
dc.date.issued2024
dc.description.abstractAerobic metabolism relies on external oxygen production through photosynthesis and its subsequent transport into each cell of the body via the cardiorespiratory system. This mechanism has successfully evolved over millions of years, enabling animals to inhabit most environments on Earth. However, the insufficient oxygen supply leads to several clinical problems, ranging from non-healing wounds to tumor resistance to therapy. Given that photosynthetic microorganisms are capable of producing oxygen and removing carbon dioxide from the environment, over the last decade, several groups worldwide have proposed their potential use as an alternative tissue oxygenation approach. While most studies have demonstrated safety and efficacy after local tissue administration, recent studies have also suggested that systemic administration could trigger intravascular photosynthesis. If successful, the development of a new generation of circulating cells, known as chlorocytes, may partially replace the role of erythrocytes in gas exchange within the body, without relying on external supply and vascular flow. This work reviews the existing literature on local and systemic administration of photosynthetic microorganisms, highlighting the main challenges in the field and potential solutions to unleash the enormous potential clinical impact of chlorocytes and intravascular photosynthesis. Key points: • Circulating photosynthetic microorganisms could deliver oxygen to tissues • Microalgae and cyanobacteria have shown safety and efficacy for oxygen delivery • Several key challenges need to be addressed for the clinical success of chlorocytes.
dc.description.funderANID-Proyecto de Exploración; Folio: 13220024
dc.description.funderANID-Beca Doctorado Naciona; Folio: 2024–21240757
dc.format.extent13 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1007/s00253-024-13285-1
dc.identifier.eissn1432-0614
dc.identifier.issn0175-7598
dc.identifier.scopusid2-s2.0-85206621672
dc.identifier.urihttps://doi.org/10.1007/s00253-024-13285-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103076
dc.identifier.wosidWOS:001338292300001
dc.information.autorucInstituto de Ingeniería Biológica y Médica;Vargas Torres Valentina Isabel; S/I; 247359
dc.information.autorucFacultad de Ciencias Biológicas; Boric P., Mauricio; 0000-0001-6735-6675; 56355
dc.information.autorucEscuela de Ingeniería; Egaña, José T.; 0000-0003-2624-6992; 1018715
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaApplied Microbiology and Biotechnology
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHypoxia
dc.subjectOxygen delivery
dc.subjectPhotosynthesis
dc.subjectMicroorganisms
dc.subjectChlorocytes
dc.subjectCyanobacteria
dc.subjectMicroalgae
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.titleTowards chlorocytes for therapeutic intravascular photosynthesis
dc.typeartículo
dc.volumen108
sipa.codpersvinculados247359
sipa.codpersvinculados56355
sipa.codpersvinculados1018715
sipa.trazabilidadORCID;2025-03-03
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