Association of adenotonsillectomy with wheezing episodes in childhood: A secondary analysis of the Childhood Adenotonsillectomy Trial

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dc.contributor.authorCastro-Rodriguez, Jose A.
dc.contributor.authorBiancardi, Fiorella
dc.contributor.authorPadilla, Oslando
dc.contributor.authorBeckhaus, Andrea A.
dc.contributor.authorTapia, Ignacio E.
dc.date.accessioned2025-01-20T20:20:06Z
dc.date.available2025-01-20T20:20:06Z
dc.date.issued2023
dc.description.abstractBackgroundObservational studies suggest that asthma/wheezing improves after adenotonsillectomy (AT). However, there is a paucity of randomized clinical trial (RCT) specifically studying the effects of AT in asthma/wheezing. Therefore, we conducted a post-hoc analysis of the Childhood Adenotonsillectomy Trial (CHAT), the largest RCT of AT in children with obstructive sleep apnea (OSA) to test the hypothesis that AT would result in fewer wheezing episodes. MethodsIn the CHAT study, 464 children with OSA, aged 5-9 years, were randomized to early AT (n = 226) or watchful waiting with supportive care (WWSC) (n = 227). For this post-hoc analysis, children were categorized as having "any wheezing" versus "no wheezing" at baseline and at 7 months of follow-up. A multivariate analysis was conducted to evaluate the association between "any wheezing" at follow-up and treatment group after controlling for several potential confounders. ResultsChildren in the "any wheezing" group were predominantly black, had more allergic rhinitis, eczema, second-hand smoke exposure, body mass index, apnea-hypopnea index (AHI), and had lower maternal education and family income than those in the "no wheezing group." In the AT arm, the prevalence of wheezing significantly decreased from baseline to follow-up (at 7 months of the intervention) (47% vs. 21.6%, p < 0.001); while in the WWSC arms did not change (45.2% vs. 43.1%, p = 0.67). In the multivariate analysis, second-hand smoke exposure, wheezing at baseline, and belong to WWSC arm (odds ratio: 3.65 [2.16-6.19]) increase the risk of wheezing at follow-up. ConclusionThis study demonstrated that AT decreased the risk of wheezing at 7 months of follow-up.
dc.fuente.origenWOS
dc.identifier.doi10.1002/ppul.26252
dc.identifier.eissn1099-0496
dc.identifier.issn8755-6863
dc.identifier.urihttps://doi.org/10.1002/ppul.26252
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92561
dc.identifier.wosidWOS:000896663000001
dc.issue.numero3
dc.language.isoen
dc.pagina.final777
dc.pagina.inicio772
dc.revistaPediatric pulmonology
dc.rightsacceso restringido
dc.subjectadenotonsillectomy
dc.subjectasthma
dc.subjectrecurrent wheezing
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation of adenotonsillectomy with wheezing episodes in childhood: A secondary analysis of the Childhood Adenotonsillectomy Trial
dc.typeartículo
dc.volumen58
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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