A guide for health professionals to interpret and use recommendations in guidelines developed with the GRADE approach

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dc.contributor.authorNeumann, Ignacio
dc.contributor.authorSantesso, Nancy
dc.contributor.authorAkl, Elie A.
dc.contributor.authorRind, David M.
dc.contributor.authorVandvik, Per Olav
dc.contributor.authorAlonso-Coello, Pablo
dc.contributor.authorAgoritsas, Thomas
dc.contributor.authorMustafa, Reem A.
dc.contributor.authorAlexander, Paul Elias
dc.contributor.authorSchuenemann, Holger
dc.contributor.authorGuyatt, Gordon H.
dc.date.accessioned2025-01-23T21:31:34Z
dc.date.available2025-01-23T21:31:34Z
dc.date.issued2016
dc.description.abstractAn increasing number of organizations worldwide are using new and improved standards for developing trustworthy clinical guidelines. One of such approaches, developed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group, offers systematic and transparent guidance in moving from evidence to recommendations. The GRADE strategy concentrates on four factors: the balance between benefits and harms, the certainty of the evidence, values and preferences, and resource considerations. However, it also considers issues around feasibility, equity, and acceptability of recommendations. GRADE distinguishes two types of recommendations: strong and weak. Strong recommendations reflect a clear preference for one alternative and should apply to all or almost all patients, obviating the need for a careful review of the evidence with each patient. Weak recommendations are appropriate when there is a close balance between desirable and undesirable consequences of alternative management strategies, uncertainty regarding the effects of the alternatives, uncertainty or variability in patients' values and preferences, or questionable cost-effectiveness. Weak recommendations usually require accessing the underlying evidence and a shared decision-making approach. Clinicians using GRADE recommendations should understand the meaning of the strength of the recommendation, be able to critically appraise the recommendation, and apply trustworthy recommendations according to their strength. (C) 2016 Elsevier Inc. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jclinepi.2015.11.017
dc.identifier.eissn1878-5921
dc.identifier.issn0895-4356
dc.identifier.urihttps://doi.org/10.1016/j.jclinepi.2015.11.017
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101472
dc.identifier.wosidWOS:000372393300008
dc.language.isoen
dc.pagina.final55
dc.pagina.inicio45
dc.revistaJournal of clinical epidemiology
dc.rightsacceso restringido
dc.subjectClinical practice guidelines
dc.subjectGRADE
dc.subjectDecision making
dc.subjectEvidence-based practice
dc.subjectRecommendations
dc.subjectMedical education
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA guide for health professionals to interpret and use recommendations in guidelines developed with the GRADE approach
dc.typeartículo
dc.volumen72
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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