Quadruple therapies show a higher eradication rate compared to standard triple therapy for <i>Helicobacter pylori</i> infection within the LEGACy consortium. A multicenter observational study in European and Latin American countries

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dc.contributor.authorMedel-Jara, Patricio
dc.contributor.authorReyes Placencia, Diego
dc.contributor.authorFuentes-Lopez, Eduardo
dc.contributor.authorCorsi, Oscar
dc.contributor.authorLatorre, Gonzalo
dc.contributor.authorAnton, Rosario
dc.contributor.authorJimenez, Elena
dc.contributor.authorMiralles-Marco, Ana
dc.contributor.authorCaballero, Carmelo
dc.contributor.authorBoggino, Hugo
dc.contributor.authorCantero, Daniel
dc.contributor.authorBarros, Rita
dc.contributor.authorSantos-Antunes, Joao
dc.contributor.authorDiez, Marc
dc.contributor.authorQuinones, Luis A.
dc.contributor.authorRiquelme, Erick
dc.contributor.authorRollan, Antonio
dc.contributor.authorCerpa, Leslie C.
dc.contributor.authorValdes, Ivania
dc.contributor.authorNyssen, Olga P.
dc.contributor.authorMoreira, Leticia
dc.contributor.authorGisbert, Javier P.
dc.contributor.authorCamargo, M. Constanza
dc.contributor.authorOrtiz-Olvera, Nayeli
dc.contributor.authorLeon-Takahashi, Alberto M.
dc.contributor.authorRuiz-Garcia, Erika
dc.contributor.authorFernandez-Figueroa, Edith A.
dc.contributor.authorGarrido, Marcelo
dc.contributor.authorOwen, Gareth I.
dc.contributor.authorCervantes, Andres
dc.contributor.authorFleitas, Tania
dc.contributor.authorRiquelme, Arnoldo
dc.date.accessioned2025-01-20T16:11:55Z
dc.date.available2025-01-20T16:11:55Z
dc.date.issued2024
dc.description.abstractIntroduction: Gastric cancer (GC) is one of the most lethal malignancies worldwide. Helicobacter pylori is the primary cause of GC; therefore, its eradication reduces the risk of developing this neoplasia. There is extensive evidence regarding quadruple therapy with relevance to the European population. However, in Latin America, data are scarce. Furthermore, there is limited information about the eradication rates achieved by antibiotic schemes in European and Latin American populations. Objective: To compare the effectiveness of standard triple therapy (STT), quadruple concomitant therapy (QCT), and bismuth quadruple therapy (QBT) in six centers in Europe and Latin America. Methods: A retrospective study was carried out based on the LEGACy registry from 2017 to 2022. Data from adult patients recruited in Portugal, Spain, Chile, Mexico, and Paraguay with confirmed H. pylori infection who received eradication therapy and confirmatory tests at least 1 month apart were included. Treatment success by each scheme was compared using a mixed multilevel Poisson regression, adjusting for patient sex and age, together with country-specific variables, including prevalence of H. pylori antibiotic resistance (clarithromycin, metronidazole, and amoxicillin), and CYP2C19 polymorphisms. Results: 772 patients were incorporated (64.64% females; mean age of 52.93 years). The total H. pylori eradication rates were 75.20% (255/339) with STT, 88.70% (159/178) with QCT, and 91.30% (191/209) with QBT. Both quadruple therapies (QCT-QBT) showed significantly higher eradication rates compared with STT, with an adjusted incidence risk ratio (IRR) of 1.25 (p: <0.05); and 1.24 (p: <0.05), respectively. The antibiotic-resistance prevalence by country, but not the prevalence of CYP2C19 polymorphism, showed a statistically significant impact on eradication success. Conclusions: Both QCT and QBT are superior to STT for H. pylori eradication when adjusted for country-specific antibiotic resistance and CYP2C19 polymorphism in a sample of individuals residing in five countries within two continents.
dc.fuente.origenWOS
dc.identifier.doi10.1002/ueg2.12605
dc.identifier.eissn2050-6414
dc.identifier.issn2050-6406
dc.identifier.urihttps://doi.org/10.1002/ueg2.12605
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90301
dc.identifier.wosidWOS:001282790700001
dc.language.isoen
dc.revistaUnited european gastroenterology journal
dc.rightsacceso restringido
dc.subjectcombination drug therapies
dc.subjectgastric cancer
dc.subjectHelicobacter pylori
dc.subjectquadruple therapy
dc.subjectstandard triple therapy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleQuadruple therapies show a higher eradication rate compared to standard triple therapy for <i>Helicobacter pylori</i> infection within the LEGACy consortium. A multicenter observational study in European and Latin American countries
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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