Royal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses

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dc.catalogadorjca
dc.contributor.authorÁlvarez, Simón
dc.contributor.authorContreras-Kallen, Pamina
dc.contributor.authorAguayo Paul, Sebastián
dc.contributor.authorRamírez, Orlando
dc.contributor.authorVallejos, Catalina
dc.contributor.authorRuiz, Jorge
dc.contributor.authorCarrasco-Gallardo, Eva
dc.contributor.authorTroncoso-Vera, Stefanie
dc.contributor.authorMorales, Bernardo
dc.contributor.authorSchuh, Christina M.A.P.
dc.date.accessioned2023-05-12T15:37:02Z
dc.date.available2023-05-12T15:37:02Z
dc.date.issued2023
dc.description.abstractApis mellifera royal jelly (RJ) is a well-known remedy in traditional medicine around the world and its versatile effects range from antibacterial to anti-inflammatory properties and pro-regenerative properties. As a glandular product, RJ has been shown to contain a substantial number of extracellular vesicles (EVs), and, in this study, we aimed to investigate the extent of involvement of RJEVs in wound healing-associated effects. Molecular analysis of RJEVs verified the presence of exosomal markers such as CD63 and syntenin, and cargo molecules MRJP1, defensin-1, and jellein-3. Furthermore, RJEVs were demonstrated to modulate mesenchymal stem cell (MSC) differentiation and secretome, as well as decrease LPS-induced inflammation in macrophages by blocking the mitogen-activated protein kinase (MAPK) pathway. In vivo studies confirmed antibacterial effects of RJEVs and demonstrated an acceleration of wound healing in a splinted mouse model. This study suggests that RJEVs play a crucial role in the known effects of RJ by modulating the inflammatory phase and cellular response in wound healing. Transfer of RJ into the clinics has been impeded by the high complexity of the raw material. Isolating EVs from the raw RJ decreases the complexity while allowing standardization and quality control, bringing a natural nano-therapy one step closer to the clinics.
dc.fechaingreso.objetodigital2023-05-12
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.omtn.2023.02.008
dc.identifier.issn2162-2531
dc.identifier.urihttps://doi.org/10.1016/j.omtn.2023.02.008
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66980
dc.information.autorucEscuela de Odontología;Aguayo Paul, Sebastián;0000-0003-0900-1993;1062336
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final552
dc.pagina.inicio541
dc.revistaMolecular Therapy Nucleic Acids
dc.rightsacceso abierto
dc.subjectInterkingdom communication
dc.subjectAnti-inflammatory extracellular vesicles
dc.subjectNano-therapydefensin-1
dc.subjectExtracellular vesicle delivery
dc.subjectHoneybee
dc.subjectApis mellifera
dc.subjectTherapeutic extracellular vesicles
dc.subjectRegenerative medicine
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRoyal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses
dc.typeartículo
dc.volumen31
sipa.codpersvinculados1062336
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