α<sub>2</sub>-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals

Simple item page
dc.contributor.authorDonoso, MV
dc.contributor.authorCarvajal, A
dc.contributor.authorParedes, A
dc.contributor.authorTomic, A
dc.contributor.authorKoenig, CS
dc.contributor.authorHuidobro-Toro, JP
dc.date.accessioned2025-01-21T01:10:36Z
dc.date.available2025-01-21T01:10:36Z
dc.date.issued2002
dc.description.abstractNeuropeptide Y (NPY) and noradrenaline (NA) are co-transmitters at many sympathetic synapses, but it is not yet clear if their release is independently regulated. To address this question, we quantified the electrically evoked release of these co-transmitters from perivascular nerve terminals to the mesenteric circulation in control and drug-treated rats. 6-Hydroxydopamine reduced the tissue content and the electrically evoked release of ir-NPY and NA as well as the rise in perfusion pressure. A 0.001 mg/kg reserpine reduced the content of ir-NPY and NA, but did not modify their release nor altered the rise in perfusion pressure elicited by the electrical stimuli. However, 0.1 mg/kg reserpine reduced both the content and release of NA but decreased only the content but not the release of ir-NPY; the rise in perfusion pressure was halved. Clonidine did not affect the release of ir-NPY while it lowered the outflow of NA, not altering the rise in perfusion pressure elicited by the electrical stimuli. Yohimbine, did not modify the release of ir-NPY but increased the NA outflow, it antagonized the clonidine effect. Therefore, presynaptic alpha(2)-adrenoceptors modulate the release of NA but not NPY, implying separate regulatory mechanisms. (C) 2002 Elsevier Science Inc. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn0196-9781
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96700
dc.identifier.wosidWOS:000178339300016
dc.issue.numero9
dc.language.isoen
dc.pagina.final1671
dc.pagina.inicio1663
dc.revistaPeptides
dc.rightsacceso restringido
dc.subjectneuropeptide Y (NPY) release
dc.subjectnoradrenaline (NA) release
dc.subjectsympathetic co-transmitter release
dc.subjectreserpine
dc.subject6-hydroxydopamine
dc.subjectalpha(2)-presynaptic receptors
dc.subjectpresynaptic regulation
dc.subjectalpha(2)-autoreceptors
dc.subject.ods02 Zero Hunger
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleα<sub>2</sub>-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals
dc.typeartículo
dc.volumen23
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas