Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits

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dc.contributor.authorAlcayaga Urbina, Julio Andrés
dc.contributor.authorRío Troncoso, Rodrigo Andre del
dc.contributor.authorMoya Céspedes, Esteban Alexis.
dc.contributor.authorFreire, Matías.
dc.contributor.authorIturriaga Agüera, Rodrigo
dc.date.accessioned2019-10-16T20:53:35Z
dc.date.available2019-10-16T20:53:35Z
dc.date.issued2018
dc.date.updated2019-10-14T19:12:32Z
dc.description.abstractAbstract Background chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it’s impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart rate variability (HRV) in rabbits subjected to chronic normobaric hypoxia (CNH; PB ~ 719 mmHg; FIO2 ~ 9.2%) for 14 days and assess the effect of autonomic control by acute bilateral vagal denervation. Results exposure to CNH stalled animal weight gain and increased the hematocrit, without affecting heart rate or arterial blood pressure. Nevertheless, Poincaré plots of the electrocardiographic R–R intervals showed a reduced distribution parallel to the line of identity, which interpreted as reduced long-term HRV. In the frequency domain, CNH reduced the very-low- (< 0.2 Hz) and high-frequency components (> 0.8 Hz) of the R–R spectrograms and produced a prominent component in the low-frequency component (0.2–0.5 Hz) of the power spectrum. In control and CNH exposed rabbits, bilateral vagotomy had no apparent effect on the short- and long-term HRV in the Poincaré plots. However, bilateral vagotomy differentially affected higher-frequency components (> 0.8 Hz); reducing it in control animals without modifying it in CNH-exposed rabbits. Conclusions These results suggest that CNH exposure shifts the autonomic balance of heart rate towards a sympathetic predominance without modifying resting heart rate or arterial blood pressure.
dc.fuente.origenBiomed Central
dc.identifier.citationBiological Research. 2018 Dec 20;51(1):57
dc.identifier.doi10.1186/s40659-018-0207-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26577
dc.issue.numeroNo.57
dc.language.isoen
dc.pagina.final14
dc.pagina.inicio1
dc.revistaBiological Researches_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherPresion arteriales_ES
dc.subject.otherRitmo cardiacoes_ES
dc.subject.otherHipoxiaes_ES
dc.titleEffects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbitses_ES
dc.typeartículo
dc.volumenVol. 51
sipa.codpersvinculados103722
sipa.codpersvinculados126608
sipa.codpersvinculados59784
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