Assessment of<i> TLL1</i> variant and risk of hepatocellular carcinoma in Latin Americans and Europeans

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dc.contributor.authorFu, Siyu
dc.contributor.authorKarim, Dhamina
dc.contributor.authorPrieto, Jhon
dc.contributor.authorBalderramo, Domingo
dc.contributor.authorFerrer, Javier Diaz
dc.contributor.authorMattos, Angelo Z.
dc.contributor.authorArrese, Marco
dc.contributor.authorCarrera, Enrique
dc.contributor.authorOliveira, Jeffrey
dc.contributor.authorDebes, Jose D.
dc.contributor.authorBoonstra, Andre
dc.date.accessioned2025-01-20T17:10:55Z
dc.date.available2025-01-20T17:10:55Z
dc.date.issued2024
dc.description.abstractIntroduction and Objectives: Tolloid like protein 1 (TLL1) rs17047200 has been reported to be associated with HCC development and liver fibrosis. However, to our knowledge, no studies have been performed on Latin Americans and comparative differences between TLL1 rs17047200 in HCC patients from Latin America and Europe are undefined. Materials and Methods: Cross-sectional analysis performed on Latin American and European individuals. We analyzed TLL1 rs17047200 on DNA from 1194 individuals, including 420 patients with HCC (86.0 % cirrhotics) and 774 without HCC (65.9 % cirrhotics). Results: TLL1 rs17047200 genotype AT/TT was not associated with HCC development in Latin Americans (OR: 0.699, 95 %CI 0.456-1.072, p = 0.101) or Europeans (OR: 0.736, 95 %CI 0.447-1.211, p = 0.228). TLL1 AT/TT was not correlated with fibrosis stages among metabolic dysfunction-associated steatotic liver disease (MASLD) patients from Latin America (OR: 0.975, 95 %CI 0.496-1.918, p = 0.941). Among Europeans, alcohol-related HCC had lower TLL1 AT/TT frequencies than cirrhosis (18.3 % versus 42.3 %, OR: 0.273, 95 %CI 0.096-0.773, p = 0.015). Conclusions: We found no evidence that the TLL1 rs17047200 AT/TT genotype is a risk factor for HCC develop-ment in Latin Americans or Europeans. A larger study integrating ethnic and etiology backgrounds is needed to determine the importance of the TLL1 SNP in HCC development.(c) 2023 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.aohep.2023.101181
dc.identifier.issn1665-2681
dc.identifier.urihttps://doi.org/10.1016/j.aohep.2023.101181
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91145
dc.identifier.wosidWOS:001132713500001
dc.issue.numero2
dc.language.isoen
dc.revistaAnnals of hepatology
dc.rightsacceso restringido
dc.subjectTLL1
dc.subjectHepatocellular carcinoma
dc.subjectLatin America
dc.subjectLiver
dc.subjectCancer
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssessment of<i> TLL1</i> variant and risk of hepatocellular carcinoma in Latin Americans and Europeans
dc.typeartículo
dc.volumen29
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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