Subchronic exposure to chlorpyrifos affects energy expenditure and detoxification capacity in juvenile Japanese quails

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dc.contributor.authorNarvaez, Cristobal
dc.contributor.authorManuel Rios, Juan
dc.contributor.authorPiriz, Gabriela
dc.contributor.authorSanchez-Hernandezc, Juan C.
dc.contributor.authorSabat, Pablo
dc.date.accessioned2025-01-23T21:32:15Z
dc.date.available2025-01-23T21:32:15Z
dc.date.issued2016
dc.description.abstractEffects of pesticides on non-target organisms have been studied in several taxa at different levels of biological organization, from enzymatic to behavioral responses. Although the physiological responses may be associated with higher energy costs, little is known about metabolic costs of pesticide detoxification in birds. To fill this gap, we exposed orally (diet) 15-d old Coturnix cotumix japonica individuals to sublethal doses of chlorpyrifos (10 and 20 mg active ingredient/kg dry food) for four weeks. Carboxylesterase (CbE), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) activities were periodically measured in multiple tissues along with measurements of resting (RMR) and maximum metabolic rates (M-sum). Furthermore, glucuronic acid in bird excreta was also assessed at the end of the trial. While CbE and BChE activities were inhibited by chlorpyrifos in all tissues during the third and fourth weeks following pesticide treatment, AChE activity was unaffected. At this sampling times, both M-sum and RMR expansibility decreased. These results suggest that the exposure to chlorpyrifos caused a negative effect on aerobic performance. Additionally, excretion rate of glucuronic acid was up to 2-fold higher in the 20-mg/kg group than in the control and 10-mg/kg chlorpyrifos groups. The inhibition of CbE and BChE activities corroborated that these enzymes are fulfilling their role as bioscavengers for organophosphate pesticides, decreasing its concentration and thus protecting AChE activity against inhibition by chlorpyrifos. (C) 2015 Elsevier Ltd. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.chemosphere.2015.09.060
dc.identifier.eissn1879-1298
dc.identifier.issn0045-6535
dc.identifier.urihttps://doi.org/10.1016/j.chemosphere.2015.09.060
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101487
dc.identifier.wosidWOS:000367774400099
dc.language.isoen
dc.pagina.final784
dc.pagina.inicio775
dc.revistaChemosphere
dc.rightsacceso restringido
dc.subjectAerobic performance
dc.subjectDetoxification
dc.subjectEsterases
dc.subjectOrganophosphorus pesticides
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSubchronic exposure to chlorpyrifos affects energy expenditure and detoxification capacity in juvenile Japanese quails
dc.typeartículo
dc.volumen144
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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