Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome

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dc.article.number111863
dc.catalogadoraba
dc.contributor.authorManjarrés Madrid, Laura
dc.contributor.authorXavier, Aline
dc.contributor.authorGonzalez Jara, Leticia Andrea
dc.contributor.authorGarrido Ahumada, Camila Florencia
dc.contributor.authorZacconi Flavia, Cristina Milagro
dc.contributor.authorRivera K.
dc.contributor.authorParra L.
dc.contributor.authorPhinikaridou A.
dc.contributor.authorBesa Correa, Cecilia
dc.contributor.authorAndía Kohnenkampf, Marcelo Edgardo
dc.date.accessioned2025-03-10T17:54:05Z
dc.date.available2025-03-10T17:54:05Z
dc.date.issued2025
dc.description.abstractMetabolic dysfunction-associated steatotic liver disease (MASLD) progression exhibits significant sex differences, with males generally developing more severe disease. This study used an endothelial nitric oxide synthase knockout (eNOS KO) murine model to investigate sex-specific MASLD progression under a Western diet intervention. Magnetic resonance imaging (MRI) assessed body composition and liver and skeletal muscle fat fraction, revealing greater visceral fat, liver volume, and liver-to-muscle fat ratios in males. Dimensionality reduction and clustering analyses identified distinct sex-specific MASLD phenotypes and progression patterns. Histological evaluations confirmed greater liver damage in males, evidenced by higher MAFLD Activity Scores. These findings highlight the critical role of sex as a biological variable in MASLD pathology and emphasize the influence of body composition and fat distribution on disease progression. The study underscores the utility of advanced imaging and analytical techniques for refining non-invasive diagnostics and guiding sex-specific interventions, paving the way for personalized MASLD management strategies.
dc.fechaingreso.objetodigital2025-03-10
dc.format.extent12 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.isci.2025.111863
dc.identifier.issn2589-0042
dc.identifier.scopusidSCOPUS_ID:85216612552
dc.identifier.urihttps://doi.org/10.1016/j.isci.2025.111863
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102467
dc.information.autorucEscuela de Medicina; Manjarrés Madrid, Laura; S/I; 1183087
dc.information.autorucEscuela de Química; Garrido Ahumada, Camila Florencia; S/I; 233870
dc.information.autorucEscuela de Medicina; Gonzalez Jara, Leticia Andrea; S/I; 1061572
dc.information.autorucEscuela de Química; Zacconi Flavia, Cristina Milagro; 0000-0002-3676-0453; 1011127
dc.information.autorucEscuela de Medicina; Besa Correa, Cecilia; 0000-0002-0015-0434; 167343
dc.information.autorucEscuela de Ingeniería; Andía Kohnenkampf, Marcelo Edgardo; 0000-0002-1251-5832; 90691
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherElsevier Inc.
dc.revistaiScience
dc.rightsacceso abierto
dc.rights.licenseAtribución/Reconocimiento-NoComercial 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.es
dc.subjectGenetics
dc.subjectHuman metabolism
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleSex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome
dc.typeartículo
dc.volumen28
sipa.codpersvinculados1183087
sipa.codpersvinculados233870
sipa.codpersvinculados1061572
sipa.codpersvinculados1011127
sipa.codpersvinculados167343
sipa.codpersvinculados90691
sipa.trazabilidadSCOPUS;2025-02-23
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