On the L-DOPA and carbidopa reactivity against pyridoxal 5′-phosphate.: A kinetic study

Simple item page
dc.contributor.authorGorostidi, GRE
dc.contributor.authorSantos, JG
dc.contributor.authorFigueroa, J
dc.contributor.authorBlanco, FG
dc.date.accessioned2025-01-21T01:30:29Z
dc.date.available2025-01-21T01:30:29Z
dc.date.issued2002
dc.description.abstractThe apparent rate constants of the formation (k(1))) and hydrolysis (k(2)) of Schiff bases formed by pyridoxal 5'-phosphate (PLP) with L-3,4-dihydroxyphenylalanine (L-DOPA) at a variable pH, 25 degreesC and an ionic strength of 0. 1 M was determined. The individual rate constants for the formation and hydrolysis of Schiff bases corresponding to the different chemical species present in the medium as a function of its acidity were also determined, as were the pK(a) values for the Schiff bases. The formation and hydrolysis rate constants of the Schiff bases were compared with those of the reaction of PLP with carbidopa (CD), showing that the reactivity Of L-DOPA and carbidopa on PLP are the same over the whole pH range studied, and that the hydrolysis rate is somewhat greater for the Schiff bases between PLP and CD than those between PLP and L-DOPA.
dc.fuente.origenWOS
dc.identifier.eissn1348-0634
dc.identifier.issn0009-2673
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96779
dc.identifier.wosidWOS:000174592200017
dc.issue.numero3
dc.language.isoen
dc.pagina.final549
dc.pagina.inicio545
dc.revistaBulletin of the chemical society of japan
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods12 Responsible Consumption and Production
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa12 Producción y consumo responsable
dc.titleOn the L-DOPA and carbidopa reactivity against pyridoxal 5′-phosphate.: A kinetic study
dc.typeartículo
dc.volumen75
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas