Aleph2, a Suspected Anxiolytic and Putative Hallucinogenic Phenylisopropylamine Derivative, Is a 5-Ht2a and 5-Ht2c Receptor Agonist

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dc.contributor.authorAcuña-Castillo, C
dc.contributor.authorScorza, C
dc.contributor.authorReyes-Parada, M
dc.contributor.authorCassels, BK
dc.contributor.authorHuidobro-Toro, JP
dc.date.accessioned2025-01-21T01:31:06Z
dc.date.available2025-01-21T01:31:06Z
dc.date.issued2000
dc.description.abstractTo assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties,Xenopus laevis oocytes were microinjected with either of the rat cRNA for the 5-HT2A or the 5-HT2C receptor. Concentration-response curves were obtained following the exposure of the oocytes to varying concentrations of either ALEPH-2 or 5-hydroxy-tryptamine (5-HT) for 10 s. ALEPH-2 is a partial agonist on the 5-HT,,receptor with a similar potency to 5-HT. In contrast, ALEPH-2 is a full 5-HT2C receptor agonist and is about 15-fold less potent than 5-HT. Pre-application of 1 muM ritanserin antagonized the responses induced by 5-HT and ALEPH-2 to the same extent; however, the 5-HT2A receptor is more sensitive to ritanserin blockade than the 5-HT2C receptor. (C) 2000 Elsevier Science Inc. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0024-3205(00)00906-1
dc.identifier.issn0024-3205
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96985
dc.identifier.urihttps://doi.org/10.1016/S0024-3205(00)00906-1
dc.identifier.wosidWOS:000165476700012
dc.issue.numero26
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final3247
dc.pagina.inicio3241
dc.relation.isformatofLife Sciences. Vol. 67, no. 26 (2000), p. [3241]-3247
dc.revistaLife sciences
dc.rightsacceso restringido
dc.subjectALEPH-2
dc.subject5-hydroxytryptamine
dc.subject5-HT2A and 5-HT2C receptors
dc.subjectphenylisopropylamine derivatives
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherHidroxitriptamina
dc.subject.otherFenilpropanolamina
dc.subject.otherFarmacología
dc.titleAleph2, a Suspected Anxiolytic and Putative Hallucinogenic Phenylisopropylamine Derivative, Is a 5-Ht2a and 5-Ht2c Receptor Agonist
dc.typeartículo
dc.volumen67
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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