Alcohol consumption during adolescence alters the hippocampal response to traumatic brain injury

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dc.catalogadorjlo
dc.contributor.authorMira, Rodrigo G.
dc.contributor.authorLira, Matías
dc.contributor.authorQuintanilla, Rodrigo A.
dc.contributor.authorCerpa Nebott, Waldo Francisco
dc.date.accessioned2024-01-29T17:48:29Z
dc.date.available2024-01-29T17:48:29Z
dc.date.issued2020
dc.description.abstractBinge drinking is the consumption of large volumes of alcohol in short periods and exerts its effects on the central nervous system, including the hippocampus. We have previously shown that binge drinking alters mitochondrial dynamics and induces neuroinflammation in the hippocampus of adolescent rats. Mild traumatic brain injury (mTBI), is regularly linked to alcohol consumption and share mechanisms of brain damage. In this context, we hypothesized that adolescent binge drinking could prime the development of brain damage generated by mTBI. We found that alcohol binge drinking induced by the “drinking in the dark” (DID) paradigm increases oxidative damage and astrocyte activation in the hippocampus of adolescent mice. Interestingly, adolescent animals submitted to DID showed decreased levels of mitofusin 2 that controls mitochondrial dynamics. When mTBI was evaluated as a second challenge, hippocampi from animals previously submitted to DID showed a reduction in dendritic spine number and a different spine profile. Mitochondrial performance could be compromised by alterations in mitochondrial fission in DID-mTBI animals. These data suggest that adolescent alcohol consumption can modify the progression of mTBI pathophysiology. We propose that mitochondrial impairment and oxidative damage could act as priming factors, modifying predisposition against mTBI effects.
dc.fechaingreso.objetodigital2025-01-07
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1016/j.bbrc.2020.05.160
dc.identifier.issn1090-2104
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2020.05.160
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81014
dc.identifier.wosidWOS:000541789500017
dc.information.autorucFacultad de Ciencias Biológicas; Mira Guzmán, Rodrigo Andrés; S/I; 215451
dc.information.autorucFacultad de Ciencias Biológicas; Lira Mendieta, Matías Sebastián; 0000-0002-3698-4553; 1050702
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott, Waldo Francisco; 0000-0001-7344-0144; 16584
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final519
dc.pagina.inicio514
dc.revistaBiochemical and Biophysical Research Communications
dc.rightsacceso restringido
dc.subjectAlcohol
dc.subjectTraumatic brain injury
dc.subjectOxidative stress
dc.subjectMitochondria
dc.subjectDendritic spine
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAlcohol consumption during adolescence alters the hippocampal response to traumatic brain injury
dc.typeartículo
dc.volumen528
sipa.codpersvinculados215451
sipa.codpersvinculados1050702
sipa.codpersvinculados16584
sipa.trazabilidadORCID;2024-01-15
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