Central and peripheral clocks are coupled by a neuropeptide pathway in <i>Drosophila</i>

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dc.contributor.authorSelcho, Mareike
dc.contributor.authorMillan, Carola
dc.contributor.authorPalacios-Munoz, Angelina
dc.contributor.authorRuf, Franziska
dc.contributor.authorUbillo, Lilian
dc.contributor.authorChen, Jiangtian
dc.contributor.authorBergmann, Gregor
dc.contributor.authorIto, Chihiro
dc.contributor.authorSilva, Valeria
dc.contributor.authorWegener, Christian
dc.contributor.authorEwer, John
dc.date.accessioned2025-01-23T21:26:17Z
dc.date.available2025-01-23T21:26:17Z
dc.date.issued2017
dc.description.abstractAnimal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone. Time information from the central clock is transmitted via the neuropeptide, sNPF, to non-clock neurons that produce the neuropeptide, PTTH. These secretory neurons then forward time information to the PG clock. We also show that the central clock exerts a dominant role on the peripheral clock. This use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.
dc.fuente.origenWOS
dc.identifier.doi10.1038/ncomms15563
dc.identifier.issn2041-1723
dc.identifier.urihttps://doi.org/10.1038/ncomms15563
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101350
dc.identifier.wosidWOS:000402306200001
dc.language.isoen
dc.revistaNature communications
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCentral and peripheral clocks are coupled by a neuropeptide pathway in <i>Drosophila</i>
dc.typeartículo
dc.volumen8
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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