Susceptibility to azoles and amphotericin B of isolates of Candida spp. Experience of a university health network, between 2004 and 2010

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dc.contributor.authorPorte, Lorena
dc.contributor.authorLeon, Pilar
dc.contributor.authorGarate, Cynthia
dc.contributor.authorMaria Guzman, Ana
dc.contributor.authorLabarca, Jaime
dc.contributor.authorGarcia, Patricia
dc.date.accessioned2024-01-10T12:43:13Z
dc.date.available2024-01-10T12:43:13Z
dc.date.issued2012
dc.description.abstractObjective: To describe antifungal susceptibility testing surveillance (December 2004-September 2010) in Candida spp., for amphotericin B, fluconazole and voriconazole, at the Laboratorio de Microbiologia, Pontificia Universidad Catolica de Chile. Method: The study was performed utilizing E test and included yeasts from invasive origin and isolates in which antifimgal susceptibility testing was asked for by the patient's physician. Results: The yeasts were mainly recovered from urine samples (n: 64), blood cultures (n: 51) and secretions (n: 24). Two hundred ninety three isolates were studied: C. albicans (38%), C. glabrata (30%), C. tropicalis (11%), C. parapsilosis (10%), C. krusei (4%) and others (7%). All Candida species were 100% susceptible to amphotericin B, except C. krusei (1/12). Fluconazole's global susceptibility in C. albicans was 91.8%, but 100% in isolates from blood cultures versus 76% in isolates from urine. C. tropicalis was 93.9% susceptible to fluconazole, C. parapsilosis, 90% and C. glabrata 30.3%. C. krusei had no susceptible isolates to fluconazole. Voriconazole resistance was mainly present in C. glabrata (11.5%). Conclusions: We recommend the study of antifungal susceptibility in isolates from invasive origin, selected urine strains and C. glabrata. Fluconazole remains effective in C. albicans from blood.
dc.fechaingreso.objetodigital2024-07-09
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0716-10182012000200005
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:22689028
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77576
dc.identifier.wosidWOS:000303085500005
dc.information.autorucMedicina;Garate C;S/I;1006778
dc.information.autorucMedicina;Garcia P ;S/I;73909
dc.information.autorucMedicina;Labarca J;S/I;62874
dc.information.autorucMedicina;Porte L ;S/I;1006794
dc.issue.numero2
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final155
dc.pagina.inicio149
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsacceso abierto
dc.subjectCandida
dc.subjectdrug resistance
dc.subjectfluconazole
dc.subjectvoriconazole
dc.subjectamphotericin B
dc.subjectANTIFUNGAL SUSCEPTIBILITY
dc.subjectINVASIVE CANDIDIASIS
dc.subjectFLUCONAZOLE SUSCEPTIBILITY
dc.subjectCASPOFUNGIN RESISTANCE
dc.subjectSPECIES DISTRIBUTION
dc.subjectBROTH MICRODILUTION
dc.subjectEPIDEMIOLOGY
dc.subjectVORICONAZOLE
dc.subjectTHERAPY
dc.subjectSURVEILLANCE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSusceptibility to azoles and amphotericin B of isolates of Candida spp. Experience of a university health network, between 2004 and 2010
dc.typeartículo
dc.volumen29
sipa.codpersvinculados1006778
sipa.codpersvinculados73909
sipa.codpersvinculados62874
sipa.codpersvinculados1006794
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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