Selective engraftment of the granulocyte compartment after allogeneic bone marrow transplantation in a patient with severe aplastic anemia

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dc.contributor.authorBarriga, FJ
dc.contributor.authorLegues, ME
dc.contributor.authorBertin, P
dc.date.accessioned2025-01-21T01:34:02Z
dc.date.available2025-01-21T01:34:02Z
dc.date.issued1996
dc.description.abstractPurpose: We present a patient with severe aplastic anemia who had partial engraftment with full chimerism after allogeneic bone marrow transplantation from an HLA identical sibling.
dc.description.abstractPatients and Methods: A 3-year-old girl with severe aplastic anemia (SAA) received a bone marrow transplantation (BMT) from an HLA identical brother 9 months after her diagnosis. Before BMT she was red blood cell transfusion dependent, had an absolute neutrophil count (ANC) of 1,000-1,500 X 10(9)/l and a platelet count of 15-19,000 X 10(9)/l. She was conditioned with 800 cGy total body irradiation (TBI) and cyclophosphamide and received 3 X 10(8) nucleated cells/kg.
dc.description.abstractResults: She reached an ANC of 1500 X 10(9)/l on day + 35 but her reticulocyte and platelet counts did not recover. A bone mar row aspirate and biopsy post BMT showed hypoplasia with marked decrease in megakaryocyte and red blood cell precursors. The granulocyte compartment showed a left shift with predominance of promyelocytes and myelocytes. The karyotype showed full chimerism (46,XY) with no 46,XX metaphases.
dc.description.abstractConclusion: This case illustrates the possibility of a bone marrow microenvironment defect as the cause of SAA.
dc.fuente.origenWOS
dc.identifier.issn1077-4114
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97506
dc.identifier.wosidWOS:A1996UH17100026
dc.issue.numero2
dc.language.isoen
dc.pagina.final217
dc.pagina.inicio216
dc.revistaJournal of pediatric hematology oncology
dc.rightsacceso restringido
dc.subjectaplastic anemia
dc.subjectbone marrow transplantaion
dc.subjectengraftment failure
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSelective engraftment of the granulocyte compartment after allogeneic bone marrow transplantation in a patient with severe aplastic anemia
dc.typeartículo
dc.volumen18
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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