Breathing pattern and gas exchange at peak exercise in COPD patients with and without tidal flow limitation at rest

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dc.contributor.authorDiaz, O
dc.contributor.authorVillafranca, C
dc.contributor.authorGhezzo, H
dc.contributor.authorBorzone, G
dc.contributor.authorLeiva, A
dc.contributor.authorMilic Emili, J
dc.contributor.authorLisboa, C
dc.date.accessioned2024-01-10T13:11:31Z
dc.date.available2024-01-10T13:11:31Z
dc.date.issued2001
dc.description.abstractExpiratory flow limitation (FL) at rest is frequently present in chronic obstructive pulmonary disease (COPD) patients. It promotes dynamic hyperinflation with a consequent decrease in inspiratory capacity (IC), Since in COPD resting IC is strongly correlated with exercise tolerance, this study hypothesized that this is due to limitation of the maximal tidal volume (VT,(max)) during exercise by the reduced IC, The present study investigated the role of tidal FL at rest on: 1) the relationship of resting IC to VT,(max) and 2) on gas exchange during peak exercise in COPD patients.
dc.description.abstractFifty-two stable COPD patients were studied at rest, using the negative expiratory pressure technique to assess the presence of FL, and during incremental symptom-limited cycling exercise to evaluate exercise performance,
dc.description.abstractAt rest, FL was present in 29 patients, In the 52 patients, a close relationship of VT,max to IC was found using non-normalized values (r = 0.77; p < 0.0001), and stepwise regression analysis selected IC as the only significant predictor of VT.max. Subgroup analysis show ed that this was also the case for patients both with and without FL (r = 0.70 and 0.76, respectively). In addition, in FL patients there was an increase (p < 0.002) in arterial carbon dioxide partial pressure at peak exercise, mainly due to a relatively lon VT,mas and consequent increase in the physiological dead space (VD)VT ratio. The arterial oxygen partial pressure also decreased at peak exercise in the FL patients (p < 0.05),
dc.description.abstractIn conclusion, in chronic obstructive pulmonary disease patients the maximal tidal volume, and hence maximal oxygen consumption, are closely related to the reduced inspiratory capacity. The flow limited patients also exhibit a significant increase in arterial carbon dioxide partial pressure and a decrease in arterial oxygen partial pressure during peak exercise.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1183/09031936.01.00057801
dc.identifier.eissn1399-3003
dc.identifier.issn0903-1936
dc.identifier.pubmedidMEDLINE:11491153
dc.identifier.urihttps://doi.org/10.1183/09031936.01.00057801
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78056
dc.identifier.wosidWOS:000169967700011
dc.information.autorucMedicina;Borzone G;S/I;99892
dc.information.autorucMedicina;Díaz O;S/I;78564
dc.information.autorucMedicina;Lisboa C;S/I;98551
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1127
dc.pagina.inicio1120
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.revistaEUROPEAN RESPIRATORY JOURNAL
dc.rightsacceso restringido
dc.subjectarterial blood gases
dc.subjectbreathing pattern
dc.subjectdynamic pulmonary hyperinflation
dc.subjectlung function
dc.subjectnegative expiratory pressure method
dc.subjectCAPACITY
dc.subjectPRESSURES
dc.subjectOBSTRUCTION
dc.subjectDYSPNEA
dc.subjectVALUES
dc.subjectVOLUME
dc.subjectMUSCLE
dc.subjectAGE
dc.subjectCO2
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBreathing pattern and gas exchange at peak exercise in COPD patients with and without tidal flow limitation at rest
dc.typeartículo
dc.volumen17
sipa.codpersvinculados99892
sipa.codpersvinculados78564
sipa.codpersvinculados98551
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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