Maqui, Calafate, and Blueberry fruits extracts treatments suppress the pathogenic interaction amongst human adipocytes and macrophages

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dc.contributor.authorOvalle-Marin, A.
dc.contributor.authorReyes-Farias, M.
dc.contributor.authorVasquez, K.
dc.contributor.authorParra-Ruiz, C.
dc.contributor.authorQuitral, V.
dc.contributor.authorJimenez, P.
dc.contributor.authorGarcia, L.
dc.contributor.authorRamirez, L. A.
dc.contributor.authorQuezada, J.
dc.contributor.authorGonzalez-Muniesa, P.
dc.contributor.authorGarcia-Diaz, D. F.
dc.date.accessioned2025-01-23T19:48:22Z
dc.date.available2025-01-23T19:48:22Z
dc.date.issued2020
dc.description.abstractBACKGROUND: Obesity occurs due to a positive energy imbalance, leading to the expansion of adipose tissue. This phenomenon triggers a chronic low-grade inflammatory state, which is associated with comorbidities development. It is, therefore, of great interest to investigate new counteracting nutritional strategies. In this regard, polyphenol-rich Chilean native fruits, Aristotelia chilensis (Maqui) and Berberis microphylla (Calafate), and also the non-Chilean Vaccinium corymbosum (Blueberry), have been associated with antioxidant and anti-inflammatory features.
dc.description.abstractOBJECTIVE: To evaluate Maqui, Calafate, and Blueberry aqueous extracts treatments on the pathogenic response of human activated macrophages and visceral adipocytes.
dc.description.abstractMETHODS: THP-1 monocyte human cell line and differentiated human visceral preadipocytes were activated (with lipopolysaccharide and TNF-a, for 48 and 24 h, respectively), and treated with the aqueous extracts. Inflammation and oxidative stress markers were assessed.
dc.description.abstractRESULTS: Lower NO and IL-6 secretion, and inhibited apoptosis in activated macrophages, were observed. Also, decreased gene expression of MCP-1 and secretion of IL-6, inhibited apoptosis, and increased levels of GSH in activated adipocytes were detected.
dc.description.abstractCONCLUSIONS: Maqui, Calafate, and Blueberry extracts showed anti-inflammatory and antioxidant responses in human macrophages and adipocytes.
dc.description.funderNational Commission for Scientific and Technological Research (CONICYT, Chile; FONDECYT)
dc.fuente.origenWOS
dc.identifier.doi10.3233/JBR-200576
dc.identifier.eissn1878-5123
dc.identifier.issn1878-5093
dc.identifier.urihttps://doi.org/10.3233/JBR-200576
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100441
dc.identifier.wosidWOS:000569162600013
dc.issue.numero3
dc.language.isoen
dc.pagina.final545
dc.pagina.inicio531
dc.revistaJournal of berry research
dc.rightsacceso restringido
dc.subjectAristotelia chilensis
dc.subjectberberis microphylla
dc.subjectvaccinium corymbosum
dc.subjectadipocytes
dc.subjectmacrophages
dc.subjectpolyphenols
dc.subjectinflammation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMaqui, Calafate, and Blueberry fruits extracts treatments suppress the pathogenic interaction amongst human adipocytes and macrophages
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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