Towards the personalization of septic shock resuscitation: The fundamentals of ANDROMEDA-SHOCK-2 trial

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dc.contributor.authorRamasco, F.
dc.contributor.authorAguilar, G.
dc.contributor.authorAldecoa, C.
dc.contributor.authorBakker, J.
dc.contributor.authorCarmona, P.
dc.contributor.authorDominguez, D.
dc.contributor.authorGaliana, M.
dc.contributor.authorHernandez, G.
dc.contributor.authorKattan, E.
dc.contributor.authorOlea, C.
dc.contributor.authorOspina-Tascon, G.
dc.contributor.authorPerez, A.
dc.contributor.authorRamos, K.
dc.contributor.authorRamos, S.
dc.contributor.authorTamayo, G.
dc.contributor.authorTuero, G.
dc.date.accessioned2025-01-20T17:07:38Z
dc.date.available2025-01-20T17:07:38Z
dc.date.issued2024
dc.description.abstractSeptic shock is a highly lethal and prevalent disease. Progressive circulatory dysfunction leads to tissue hypoperfusion and hypoxia, eventually evolving to multiorgan dysfunction and death. Prompt resuscitation may revert these pathogenic mechanisms, restoring oxygen delivery and organ function. High heterogeneity exists among the determinants of circulatory dysfunction in septic shock, and current algorithms provide a stepwise and standardized approach to conduct resuscitation. This review provides the pathophysiological and clinical rationale behind ANDROMEDA-SHOCK2, an ongoing multicenter randomized controlled trial that aims to compare a personalized resuscitation strategy based on clinical phenotyping and peripheral perfusion assessment, versus standard of care, in early septic shock resuscitation. (c) 2023 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Anestesiologia, Reanimacion y Terapeutica del Dolor.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.redar.2023.07.006
dc.identifier.eissn2340-3284
dc.identifier.issn0034-9356
dc.identifier.urihttps://doi.org/10.1016/j.redar.2023.07.006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90877
dc.identifier.wosidWOS:001185274400001
dc.issue.numero2
dc.language.isoen
dc.pagina.final124
dc.pagina.inicio112
dc.revistaRevista espanola de anestesiologia y reanimacion
dc.rightsacceso restringido
dc.subjectANDROMEDA-SHOCK trial
dc.subjectSepsis
dc.subjectSeptic shock
dc.subjectPulse pressure
dc.subjectDiastolic blood pressure
dc.subjectCapillary refill time
dc.subjectFluid responsiveness
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTowards the personalization of septic shock resuscitation: The fundamentals of ANDROMEDA-SHOCK-2 trial
dc.typeartículo
dc.volumen71
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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