Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes

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dc.contributor.authorGuzman Gutierrez, Enrique
dc.contributor.authorAbarzua, Fernando
dc.contributor.authorBelmar, Cristian
dc.contributor.authorNien, Jyh K.
dc.contributor.authorRamirez, Marco A.
dc.contributor.authorArroyo, Pablo
dc.contributor.authorSalomon, Carlos
dc.contributor.authorWestermeier, Francisco
dc.contributor.authorPuebla, Carlos
dc.contributor.authorLeiva, Andrea
dc.contributor.authorCasanello, Paola
dc.contributor.authorSobrevia, Luis
dc.date.accessioned2024-01-10T12:39:08Z
dc.date.available2024-01-10T12:39:08Z
dc.date.issued2011
dc.description.abstractGestational diabetes mellitus (GDM) is a syndrome compromising the health of the mother and the fetus. Endothelial damage and reduced metabolism of the vasodilator adenosine occur and fetal hyperinsulinemia associated with deficient insulin response and a metabolic rather than mitogenic phenotype is characteristic of this pathology. These phenomena lead to endothelial dysfunction of the fetoplacental unit. Major databases were searched for the relevant literature in the field. Special attention was placed on publications related with diabetes and hormone/metabolic disorders. We aimed to summarize the information regarding insulin sensitivity changes in GDM and the role of adenosine in this phenomenon. Evidence supporting the possibility that fetal endothelial dysfunction involves a functional link between adenosine and insulin signaling in the fetal endothelium from GDM pregnancies is summarized. Since insulin acts via membrane receptors type A (preferentially associated with mitogenic responses) or type B (preferentially associated with metabolic responses), a differential activation of these receptors in this syndrome is proposed.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) Chile
dc.description.funderPrograma de Investigacion Interdisciplinario (PIA) from Comision Nacional de Investigacion en Ciencia y Tecnologia (CONICYT)
dc.description.funderApoyo de Tesis CONICYT, Chile
dc.description.funderDireccion de Investigacion
dc.description.funderVicerrectoria Academica (Anillos)
dc.description.funderUniversidad de Antofagasta, Chile
dc.description.funderFaculty of Medicine, Pontificia Universidad Catolica de Chile
dc.fechaingreso.objetodigital2024-05-17
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.2174/157016111797484062
dc.identifier.eissn1875-6212
dc.identifier.issn1570-1611
dc.identifier.pubmedidMEDLINE:22022830
dc.identifier.urihttps://doi.org/10.2174/157016111797484062
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77151
dc.identifier.wosidWOS:000299562400012
dc.information.autorucMedicina;Abarzua F ;S/I;84110
dc.information.autorucMedicina;Arroyo P ;S/I;121667
dc.information.autorucMedicina;Belmar C ;S/I;82096
dc.information.autorucMedicina;Casanello P;S/I;146772
dc.information.autorucCiencias Biológicas;Guzman E ;S/I;197588
dc.information.autorucMedicina;Leiva A ;S/I;3362
dc.information.autorucCiencias Biológicas;Puebla C;S/I;124965
dc.information.autorucCiencias Biológicas;Ramirez M;S/I;101688
dc.information.autorucMedicina;Salomon C ;S/I;189546
dc.information.autorucMedicina;Sobrevia L ;S/I;1002656
dc.information.autorucCiencias Biológicas;Westermeier F ;S/I;181374
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final762
dc.pagina.inicio750
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.revistaCURRENT VASCULAR PHARMACOLOGY
dc.rightsacceso restringido
dc.subjectAdenosine
dc.subjectendothelium
dc.subjectfetus
dc.subjectgestational diabetes
dc.subjectinsulin receptor
dc.subjectplacenta
dc.subjectL-ARGININE TRANSPORT
dc.subjectSLC29A1 PROMOTER ACTIVITY
dc.subjectCORONARY FLOW RESERVE
dc.subjectNITRIC-OXIDE
dc.subjectRECEPTOR ISOFORMS
dc.subjectSKELETAL-MUSCLE
dc.subjectGLUCOSE-UPTAKE
dc.subjectELEVATED GLUCOSE
dc.subjectHYBRID RECEPTORS
dc.subjectHUMAN PLACENTA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFunctional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes
dc.typeartículo
dc.volumen9
sipa.codpersvinculados84110
sipa.codpersvinculados121667
sipa.codpersvinculados82096
sipa.codpersvinculados146772
sipa.codpersvinculados197588
sipa.codpersvinculados3362
sipa.codpersvinculados124965
sipa.codpersvinculados101688
sipa.codpersvinculados189546
sipa.codpersvinculados1002656
sipa.codpersvinculados181374
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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