Total mutational load and clinical features as predictors of the metastatic status in lung adenocarcinoma and squamous cell carcinoma patients

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dc.article.number373
dc.contributor.authorOróstica, Karen Y.
dc.contributor.authorSaez-Hidalgo, Juan
dc.contributor.authorRojas de Santiago, Pamela Roxana
dc.contributor.authorRivas, Solange
dc.contributor.authorContreras, Sebastian
dc.contributor.authorNavarro, Gonzalo
dc.contributor.authorAsenjo, Juan A.
dc.contributor.authorOlivera-Nappa, Álvaro
dc.contributor.authorArmisén, Ricardo
dc.date.accessioned2022-09-22T13:21:29Z
dc.date.available2022-09-22T13:21:29Z
dc.date.issued2022
dc.date.updated2022-08-21T00:04:02Z
dc.description.abstractBackground: Recently, extensive cancer genomic studies have revealed mutational and clinical data of large cohorts of cancer patients. For example, the Pan-Lung Cancer 2016 dataset (part of The Cancer Genome Atlas project), summarises the mutational and clinical profiles of different subtypes of Lung Cancer (LC). Mutational and clinical signatures have been used independently for tumour typification and prediction of metastasis in LC patients. Is it then possible to achieve better typifications and predictions when combining both data streams? Methods: In a cohort of 1144 Lung Adenocarcinoma (LUAD) and Lung Squamous Cell Carcinoma (LSCC) patients, we studied the number of missense mutations (hereafter, the Total Mutational Load TML) and distribution of clinical variables, for different classes of patients. Using the TML and different sets of clinical variables (tumour stage, age, sex, smoking status, and packs of cigarettes smoked per year), we built Random Forest classification models that calculate the likelihood of developing metastasis. Results: We found that LC patients different in age, smoking status, and tumour type had significantly different mean TMLs. Although TML was an informative feature, its effect was secondary to the "tumour stage" feature. However, its contribution to the classification is not redundant with the latter; models trained using both TML and tumour stage performed better than models trained using only one of these variables. We found that models trained in the entire dataset (i.e., without using dimensionality reduction techniques) and without resampling achieved the highest performance, with an F1 score of 0.64 (95%CrI [0.62, 0.66]). Conclusions: Clinical variables and TML should be considered together when assessing the likelihood of LC patients progressing to metastatic states, as the information these encode is not redundant. Altogether, we provide new evidence of the need for comprehensive diagnostic tools for metastasis.
dc.format.extent11 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationJournal of Translational Medicine. 2022 Aug 18;20(1):373
dc.identifier.doi10.1186/s12967-022-03572-8
dc.identifier.urihttps://doi.org/10.1186/s12967-022-03572-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/64826
dc.information.autorucFacultad de ciencias biológicas ; Rojas de Santiago, Pamela Roxana ; S/I ; 195482
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaJournal of Translational Medicine
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectRandom forestes_ES
dc.subjectSmokinges_ES
dc.subjectClinical variableses_ES
dc.subjectLung adenocarcinoma (LUAD)es_ES
dc.subjectLung squamous cell carcinoma (LSCC) and metastasises_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTotal mutational load and clinical features as predictors of the metastatic status in lung adenocarcinoma and squamous cell carcinoma patientses_ES
dc.typeartículo
dc.volumen20
sipa.codpersvinculados195482
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