FEVER OF UNEXPLAINED ORIGIN, BIOCHEMICAL CUSHINGS-DISEASE AND CEREBRAL DYSRHYTHMIA CORRECTED BY VALPROATE SODIUM
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Date
1985
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Abstract
A patient with cerebral dysrhythmia and fever of unexplained origin for 2 yr is described. She had elevated and nonsuppressible levels of urinary 17-hydroxycorticosteroids but no clinical features of hypercortisolism. Treatment with valproate sodium corrected all the abnormalities. Cerebral dysrhythmia may affect the hypothalamic mechanisms of body temperature and regulation of adrenocorticotropic hormone levels.