Clinical and serological profile of asymptomatic and non- severe symptomatic COVID-19 cases: Lessons from a longitudinal study in primary care in Latin America

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dc.contributor.authorPuschel, Klaus
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorPenaloza, Blanca
dc.contributor.authorAbarca, Katia
dc.contributor.authorRojas, Maria-Paulina
dc.contributor.authorTellez, Alvaro
dc.contributor.authorMoore, Philippa
dc.contributor.authorMaria Cea, Ana
dc.contributor.authorWilson, Carlos
dc.contributor.authorCid, Vicente
dc.contributor.authorMontero, Joaquin
dc.date.accessioned2025-01-20T23:55:52Z
dc.date.available2025-01-20T23:55:52Z
dc.date.issued2021
dc.description.abstractBackground: Chile has one of the highest incidences of COVID-19 infection in the world. Primary care can play a key role in early detection and containment of the disease. There is a lack of information on the clinical profile of patients with suspected COVID-19 in primary care, and controversy on the effectiveness of rapid serologic tests in the diagnosis and surveillance of the disease. Aim: To assess the effectiveness of rapid serologic testing in detection and surveillance of COVID-19 cases in primary care. Design & setting: A longitudinal study was undertaken, which was based on a non-random sample of 522 participants, including 304 symptomatic patients and 218 high -risk asymptomatic individuals. They were receiving care at four primary health clinics in an underserved area in Santiago, Chile. Method: The participants were systematically assessed and tested for COVID-19 with transcriptase- polymerase chain reaction (RT-PCR) and serology at baseline, and were followed clinically and serologically for 3 weeks. Results: The prevalence rate of RT-PCR confirmed COVID-19 cases were 3.5 times higher in symptomatic patients (27.5%; 95% confidence interval [CI] = 22.1 to 32.8) compared with asymptomatic participants (7.9%; 95% CI = 4.3 to 11.6). Similarly, the immune response was significantly different between groups. Sensitivity of serologic testing was 57.8% (95% CI = 44.8 to 70.1) during the third week follow- up and specificity was 98.4% (95% CI = 95.5 to 99.7). Conclusion: Rapid serologic testing is ineffective for detecting asymptomatic or non- severe cases COVID-19 at early stages of the disease, but can be of value for surveillance of immunity response in primary care. The clinical profile and immune response of patients with COVID-19 in primary differs from those in hospital- based populations.
dc.fuente.origenWOS
dc.identifier.doi10.3399/bjgpopen20X101137
dc.identifier.eissn2398-3795
dc.identifier.urihttps://doi.org/10.3399/bjgpopen20X101137
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95116
dc.identifier.wosidWOS:001124719200016
dc.issue.numero1
dc.language.isoen
dc.revistaBjgp open
dc.rightsacceso restringido
dc.subjectAuthor COVID-19
dc.subjectcoronavirus
dc.subjectprimary health Latin America
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical and serological profile of asymptomatic and non- severe symptomatic COVID-19 cases: Lessons from a longitudinal study in primary care in Latin America
dc.typeartículo
dc.volumen5
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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