Characterization of the Fungitoxic Activity on Botrytis cinerea of N-phenyl-driman-9-carboxamides

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dc.contributor.authorMelo, Ricardo
dc.contributor.authorArmstrong, Veronica
dc.contributor.authorNavarro, Freddy
dc.contributor.authorCastro, Paulo
dc.contributor.authorMendoza, Leonora
dc.contributor.authorCotoras, Milena
dc.date.accessioned2025-01-20T22:04:28Z
dc.date.available2025-01-20T22:04:28Z
dc.date.issued2021
dc.description.abstractA total of 12 compounds were synthesized from the natural sesquiterpene (-) drimenol (compounds 4 to 15). The synthesized compounds corresponded to N-phenyl-driman-9-carboxamide derivatives, similar to some fungicides that inhibit the electron-transport chain. Their structures were characterized and confirmed by H-1 NMR, C-13 NMR spectroscopy, and mass spectrometry. Compounds 5 to 15 corresponded to novel compounds. The effect of the compounds on the mycelial growth of Botrytis cinerea was evaluated. Methoxylated and chlorinated compounds in the aromatic ring (compounds 6, 7, 12, and 13) exhibited the highest antifungal activity with IC50 values between 0.20 and 0.26 mM. On the other hand, the effect on conidial germination of B. cinerea of one methoxylated compound (6) and one chlorinated compound (7) was analyzed, and no inhibition was observed. Additionally, compound 7 decreased 36% the rate of oxygen consumption by germinating conidia.
dc.fuente.origenWOS
dc.identifier.doi10.3390/jof7110902
dc.identifier.eissn2309-608X
dc.identifier.urihttps://doi.org/10.3390/jof7110902
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94090
dc.identifier.wosidWOS:000726704800001
dc.issue.numero11
dc.language.isoen
dc.revistaJournal of fungi
dc.rightsacceso restringido
dc.subjectBotrytis cinerea
dc.subjectantifungal activity
dc.subjectN-phenyl-driman-9-carboxamides
dc.subjectmode of action
dc.subjectoxidative phosphorylation inhibitors
dc.subject.ods02 Zero Hunger
dc.subject.ods13 Climate Action
dc.subject.odspa02 Hambre cero
dc.subject.odspa13 Acción por el clima
dc.titleCharacterization of the Fungitoxic Activity on Botrytis cinerea of N-phenyl-driman-9-carboxamides
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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