Airway wall attenuation: a biomarker of airway disease in subjects with COPD

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dc.contributor.authorWashko, George R.
dc.contributor.authorDransfield, Mark T.
dc.contributor.authorEstepar, Raul San Jose
dc.contributor.authorDiaz, Alejandro
dc.contributor.authorMatsuoka, Shin
dc.contributor.authorYamashiro, Tsuneo
dc.contributor.authorHatabu, Hiroto
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorBailey, William C.
dc.contributor.authorReilly, John J.
dc.date.accessioned2024-01-10T12:04:09Z
dc.date.available2024-01-10T12:04:09Z
dc.date.issued2009
dc.description.abstractWashko GR, Dransfield MT, Estepar RS, Diaz A, Matsuoka S, Yamashiro T, Hatabu H, Silverman EK, Bailey WC, Reilly JJ. Airway wall attenuation: a biomarker of airway disease in subjects with COPD. J Appl Physiol 107: 185-191, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.00216.2009.-The computed tomographic (CT) densities of imaged structures are a function of the CT scanning protocol, the structure size, and the structure density. For objects that are of a dimension similar to the scanner point spread function, CT will underestimate true structure density. Prior investigation suggests that this process, termed contrast reduction, could be used to estimate the strength of thin structures, such as cortical bone. In this investigation, we endeavored to exploit this process to provide a CT-based measure of airway disease that can assess changes in airway wall thickening and density that may be associated with the mural remodeling process in subjects with chronic obstructive pulmonary disease (COPD). An initial computer-based study using a range of simulated airway wall sizes and densities suggested that CT measures of airway wall attenuation could detect changes in both wall thickness and structure density. A second phantom-based study was performed using a series of polycarbonate tubes of known density. The results of this again demonstrated the process of contrast reduction and further validated the computer-based simulation. Finally, measures of airway wall attenuation, wall thickness, and wall area (WA) divided by total cross-sectional area, WA percent (WA%), were performed in a cohort of 224 subjects with COPD and correlated with spirometric measures of lung function. The results of this analysis demonstrated that wall attenuation is comparable to WA% in predicting lung function on univariate correlation and remain as a statistically significant correlate to the percent forced expiratory volume in 1 s predicted when adjusted for measures of both emphysema and WA%. These latter findings suggest that the quantitative assessment of airway wall attenuation may offer complementary information to WA% in characterizing airway disease in subjects with COPD.
dc.description.funderNational Heart, Lung, and Blood Institute (NHLBI)
dc.description.funderParker B. Francis Foundation
dc.description.funderSiemens
dc.description.funderNATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1152/japplphysiol.00216.2009
dc.identifier.eissn1522-1601
dc.identifier.issn8750-7587
dc.identifier.pubmedidMEDLINE:19407254
dc.identifier.urihttps://doi.org/10.1152/japplphysiol.00216.2009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75702
dc.identifier.wosidWOS:000267535800027
dc.information.autorucMedicina;Díaz A;S/I;104496
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final191
dc.pagina.inicio185
dc.publisherAMER PHYSIOLOGICAL SOC
dc.revistaJOURNAL OF APPLIED PHYSIOLOGY
dc.rightsacceso restringido
dc.subjectcomputed tomography
dc.subjectcontrast reduction
dc.subjectCOMPUTED-TOMOGRAPHY
dc.subjectDIMENSIONS
dc.subjectEMPHYSEMA
dc.subjectTHICKNESS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAirway wall attenuation: a biomarker of airway disease in subjects with COPD
dc.typeartículo
dc.volumen107
sipa.codpersvinculados104496
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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