Vertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile. Preliminary Report (2005-2008)

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dc.contributor.authorApt, Werner
dc.contributor.authorZulantay, Ines
dc.contributor.authorSolari, Aldo
dc.contributor.authorOrtiz, Sylvia
dc.contributor.authorOddo, David
dc.contributor.authorCorral, Gabriela
dc.contributor.authorTruyens, Carine
dc.contributor.authorCarlier, Yves
dc.date.accessioned2024-01-10T13:09:54Z
dc.date.available2024-01-10T13:09:54Z
dc.date.issued2010
dc.description.abstractCongenital Chagas disease acquired special importance in Chile after the certification of the control of Triatoma infestans and transmission by blood donors affected with Trypanosoma cruzi. In order to establish adequate protocols for intervention and control in infected mother-neonate pairs in endemic zones of Chagas disease, we present partial results (2005-2008) of a pilot project which is being carried out in the Province of Choapa, IV Region, Chile, whose objectives are: determine the current prevalence of the disease in pregnant women, estimate the incidence of vertical transmission of T. cruzi to newborns, determine the lineages of the parasite present in mothers who do and do not transmit the disease, determine the prevalence of Chagas disease in maternal grandmothers of neonates and study placental histopathology. Preliminary results indicated that in this study period, 3.7% of the women who gave birth in the Province have Chagas disease and 2.5% of their newborns were infected. The most frequent T. cruzi genotypes found in mothers studied during pregnancy were TCI and TCIId, either alone or in mixed infections. A high percentage (74.3%) of the grandmothers studied was infected with the parasite. In 29 placentas from mothers with Chagas disease we observed edema, necrosis, fibrinoid deposits and slight lymphoplasmocyte infiltration. In three placentas we found erythroblastosis and in one of them amastigote forms of T. cruzi; this was one of the cases of congenital infection. The evaluation of the diagnostic and control protocols generated will allow us to determine if it has been possible to modify the natural history of vertical transmission of T. cruzi in Chile.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT-Chile)
dc.description.funderUniversity of Chile
dc.description.funderValona Region, Belgium
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0716-97602010000300002 
dc.identifier.eissn0717-6287
dc.identifier.issn0716-9760
dc.identifier.pubmedidMEDLINE:21249297
dc.identifier.uri10.4067/S0716-97602010000300002 
dc.identifier.wosidWOS:000282838300002
dc.information.autorucMedicina;Oddo D;S/I;102247
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final274
dc.pagina.inicio269
dc.publisherSOC BIOLGIA CHILE
dc.revistaBIOLOGICAL RESEARCH
dc.rightsacceso abierto
dc.subjectCongenital Chagas disease
dc.subjectProvince of Choapa
dc.subjectmultidisciplinary study
dc.subjectCONGENITAL CHAGAS-DISEASE
dc.subjectTRIATOMA-INFESTANS
dc.subjectINFECTION
dc.subjectNIFURTIMOX
dc.subjectGENOTYPES
dc.subjectPCR
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleVertical transmission of Trypanosoma cruzi in the Province of Choapa, IV Region, Chile. Preliminary Report (2005-2008)
dc.typeartículo
dc.volumen43
sipa.codpersvinculados102247
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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