Deletion of a prophage-like element causes attenuation of <i>Salmonella enterica</i> serovar Enteritidis and promotes protective immunity

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dc.contributor.authorAraya, Daniela V.
dc.contributor.authorQuiroz, Tania S.
dc.contributor.authorTobar, Hugo E.
dc.contributor.authorLizana, Rodrigo J.
dc.contributor.authorQuezada, Carolina P.
dc.contributor.authorSantiviago, Carlos A.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorBueno, Susan M.
dc.date.accessioned2025-01-21T00:05:21Z
dc.date.available2025-01-21T00:05:21Z
dc.date.issued2010
dc.description.abstractSalmonella enterica serovar Enteritidis (S Enteritidis) is a wide host range serovar belonging to the S. enterica genus. Worldwide, it is one of the most frequent causes of food borne disease Similar to S. Typhimurium, some virulence genes of S. Enteritidis are located in pathogenicity islands and prophages. In this study we have generated a mutant strain of S. Enteritidis lacking a prophage-like element, denominated phi SE12. The resulting mutant strain was attenuated and promoted protective immunity in infected mice Although S Enteritidis strains lacking the complete prophage phi SE12 remained capable of surviving inside phagocytic cells, they showed a significantly reduced capacity to colonize internal organs and failed to cause lethal disease in mice. Consistent with these data, infection with S Enteritidis strains lacking prophage phi SE12 promoted the production of anti-Salmonella IgG antibodies and led to protection against a challenge with virulent strains of S Enteritidis. These results suggest that strains lacking this prophage can induce a protective immunity in mice and be considered as potential attenuated vaccines against S Enteritidis. (C) 2010 Elsevier Ltd All rights reserved
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.vaccine.2010.05.073
dc.identifier.eissn1873-2518
dc.identifier.issn0264-410X
dc.identifier.urihttps://doi.org/10.1016/j.vaccine.2010.05.073
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95544
dc.identifier.wosidWOS:000281002200012
dc.issue.numero33
dc.language.isoen
dc.pagina.final5466
dc.pagina.inicio5458
dc.revistaVaccine
dc.rightsacceso restringido
dc.subjectSalmonella enterica serovar Enteritidis
dc.subjectProphage
dc.subjectBacterial immunity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDeletion of a prophage-like element causes attenuation of <i>Salmonella enterica</i> serovar Enteritidis and promotes protective immunity
dc.typeartículo
dc.volumen28
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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