Impaired cardiac autophagy in patients developing postoperative atrial fibrillation

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dc.contributor.authorGarcia, Lorena
dc.contributor.authorVerdejo, Hugo E.
dc.contributor.authorKuzmicic, Jovan
dc.contributor.authorZalaquett, Ricardo
dc.contributor.authorGonzalez, Sergio
dc.contributor.authorLavandero, Sergio
dc.contributor.authorCorbalan, Ramon
dc.date.accessioned2024-01-10T12:05:58Z
dc.date.available2024-01-10T12:05:58Z
dc.date.issued2012
dc.description.abstractObjectives: Postoperative atrial fibrillation (POAF) is a common complication after on-pump heart surgery. Several histologic abnormalities, such as interstitial fibrosis and vacuolization, have been described in atrial samples from patients developing POAF. This ultrastructural remodeling has been associated with the establishment of a proarrhythmic substrate. We studied whether atrial autophagy is activated in patients who develop POAF.
dc.description.abstractMethods: A total of 170 patients in sinus rhythm who had undergone elective coronary artery bypass grafting were included. Systemic inflammatory markers were measured at baseline and 72 hours after surgery. During the procedure, samples of the right atrial appendages were obtained for evaluation of remodeling by light and electron microscopy. Protein ubiquitination and autophagy-related LC3B processing were assessed by Western blot.
dc.description.abstractResults: Of these patients, 22% developed POAF. The level of high-sensitivity C-reactive protein, fibrosis, inflammation, myxoid degeneration, and ubiquitin-aggregates in the atria did not differ between patients with and without POAF. Electron microphotographs of those with POAF showed a significant accumulation of autophagic vesicles and lipofuscin deposits. Total protein ubiquitination was similar in the patients with and without POAF, but LC3B processing was markedly reduced in those with POAF, suggesting a selective impairment in autophagic flow.
dc.description.abstractConclusions: This study provides novel evidence that ultrastructural atrial remodeling characterized by an impaired cardiac autophagy is present in patients developing POAF after coronary artery bypass surgery. (J Thorac Cardiovasc Surg 2012;143:451-9)
dc.description.funderFONDECYT
dc.description.funderFONDAP
dc.description.funderCONICYT, Chile
dc.fechaingreso.objetodigital17-04-2024
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jtcvs.2011.07.056
dc.identifier.eissn1097-685X
dc.identifier.issn0022-5223
dc.identifier.pubmedidMEDLINE:21885071
dc.identifier.urihttps://doi.org/10.1016/j.jtcvs.2011.07.056
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76095
dc.identifier.wosidWOS:000299318000034
dc.information.autorucMedicina;Corbalan R ;S/I;98700
dc.information.autorucMedicina;Gonzalez S ;S/I;99856
dc.information.autorucMedicina;Verdejo H;S/I;1001175
dc.information.autorucMedicina;Zalaquett R ;S/I;100042
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherMOSBY-ELSEVIER
dc.revistaJOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
dc.rightsacceso restringido
dc.subjectCALCIUM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImpaired cardiac autophagy in patients developing postoperative atrial fibrillation
dc.typeartículo
dc.volumen143
sipa.codpersvinculados98700
sipa.codpersvinculados99856
sipa.codpersvinculados1001175
sipa.codpersvinculados100042
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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