The role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor

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dc.catalogadorvdr
dc.contributor.authorVecchiola Cárdenas, Andrea Paola
dc.contributor.authorUslar N., Thomas
dc.contributor.authorFriedrich, Isidora
dc.contributor.authorAguirre, Joaquín
dc.contributor.authorSandoval, Alejandra
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorTapia Castillo, Alejandra
dc.contributor.authorMartínez García, Alejandra Constanza
dc.contributor.authorFardella B., Carlos
dc.date.accessioned2024-11-22T15:30:18Z
dc.date.available2024-11-22T15:30:18Z
dc.date.issued2024
dc.description.abstractBlood pressure (BP) regulation is a complex process involving various hormones, including aldosterone and its mineralocorticoid receptor. Mineralocorticoid receptor is expressed in several tissues, including the kidney, and plays a crucial role in regulating BP by controlling the sodium and water balance. During different stages of life, hormonal changes can affect mineralocorticoid receptor activity and aldosterone levels, leading to changes in BP. Increasing evidence suggests that sex steroids modulate aldosterone levels. Estrogens, particularly estradiol, mediate aldosterone biosynthesis by activating classical estrogen receptors and the G protein-coupled receptor. Progesterone acts as an anti-mineralocorticoid by inhibiting the binding of aldosterone to the mineralocorticoid receptor. Moreover, progesterone inhibits aldosterone synthase enzymes. The effect of testosterone on aldosterone synthesis is still a subject of debate. However, certain studies show that testosterone downregulates the mRNA levels of aldosterone synthase, leading to decreased plasma aldosterone levels.
dc.fechaingreso.objetodigital2024-11-22
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.fuente.origenORCID
dc.identifier.doi10.1097/XCE.0000000000000305
dc.identifier.eissn2574-0954
dc.identifier.urihttps://doi.org/10.1097/XCE.0000000000000305
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88645
dc.identifier.wosidWOS:001286714100001
dc.information.autorucEscuela de Medicina; Vecchiola Cárdenas, Andrea Paola; S/I; 123319
dc.information.autorucEscuela de Medicina; Uslar N., Thomas; 0000-0001-7213-855X; 187161
dc.information.autorucEscuela de Medicina; Friedrich, Isidora; S/I; 1135620
dc.information.autorucEscuela de Medicina; Aguirre, Joaquín; S/I; 1089206
dc.information.autorucEscuela de Medicina; Carvajal, Cristian A.; 0000-0002-0668-412X; 8586
dc.information.autorucEscuela de Medicina; Tapia Castillo, Alejandra; 0000-0002-6081-1468; 1012854
dc.information.autorucEscuela de Medicina; Martínez García, Alejandra Constanza; 0000-0002-8484-8126; 199879
dc.information.autorucEscuela de Medicina; Fardella B., Carlos; 0000-0002-5500-4434; 66235
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final7
dc.pagina.inicio1
dc.revistaCardiovascular Endocrinology & Metabolism
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAldosterone aldosterone biosynthesis
dc.subjectMineralocorticoid receptor
dc.subjectSexual steroids
dc.subjectCYP11B2
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe role of sex hormones in aldosterone biosynthesis and their potential impact on its mineralocorticoid receptor
dc.typeartículo
dc.volumen13
sipa.codpersvinculados123319
sipa.codpersvinculados187161
sipa.codpersvinculados1135620
sipa.codpersvinculados1089206
sipa.codpersvinculados8586
sipa.codpersvinculados1012854
sipa.codpersvinculados199879
sipa.codpersvinculados66235
sipa.trazabilidadWOS;2024-08-17
sipa.trazabilidadORCID;2024-11-18
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