A Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile

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dc.catalogadordfo
dc.contributor.authorCortés Arancibia, Sandra
dc.contributor.authorZúñiga-Venegas, Liliana
dc.contributor.authorPancetti, Floria
dc.contributor.authorCovarrubias, Alejandra
dc.contributor.authorRamírez-Santana, Muriel
dc.contributor.authorAdaros, Héctor
dc.contributor.authorMuñoz, Luis
dc.date.accessioned2024-01-22T16:22:20Z
dc.date.available2024-01-22T16:22:20Z
dc.date.issued2021
dc.description.abstractChile is a mining country, where waste mining is frequently found in the vicinity of inhabited areas. To explore the association between metal exposure and alterations in glucose metabolism, inflammatory status, and oxidative stress in individuals with chronic exposure to metals, a cross-sectional study was performed with 25 volunteers, between 45–65 years old. Inductive coupled plasma mass spectrometry (ICP-MS) was used to measure urinary levels of total arsenic (As) and its metabolites, cooper, nickel, chromium, and lead. Lipid profile, glucose, and insulin were measured in blood, as well as inflammation (interleukin-6, IL-6) and oxidative stress (8-hydroxy-2′deoxyguanosine, 8-OHdG) markers. Increased levels of Low-density lipoprotein, high-density lipoproteins, cholesterol and 8-OHdG, and the index for homeostasis model assessment—insulin resistance (HOMA-IR) were observed in 72%, 60%, and 56% of the volunteers, respectively. Blood-glucose levels were correlated with dimethylarsinic acid (DMA) (R2 = 0.47, p = 0.019), inorganic As (Asi) (R2 = 0.40, p = 0.012), and Ni (R2 = 0.56; p = 0.044). The models with these compounds explained 72% of the glycemia variability (βDMA = −6.47; βAsi = 6.68; βNi = 6.87). Ni showed a significantly influence on IL-6 variability (β = 0.85: R2 = 0.36). Changes in glycemia could be related to exposure to low levels of Asi and Ni, representing risk factors for metabolic diseases. Body mass index would confuse the relation between IL-6 and Ni levels, probably due to known chronic inflammation present in obese people.
dc.fechaingreso.objetodigital2024-05-09
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3390/ijerph18041419
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80883
dc.information.autorucEscuela de Medicina; Cortés Arancibia, Sandra; 0000-0003-3293-1419; 1005970
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaInternational Journal of Enviromental Research and Public Health
dc.rightsacceso abierto
dc.subjectMetabolic disorders
dc.subjectMetal exposure
dc.subjectGlycemia
dc.subjectCholesterol
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.titleA Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile
dc.typeartículo
sipa.codpersvinculados1005970
sipa.trazabilidadConveris;20-07-2021
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