Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α

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dc.contributor.authorAljabali, Alaa A. A.
dc.contributor.authorBakshi, Hamid A.
dc.contributor.authorHakkim, Faruck L.
dc.contributor.authorHaggag, Yusuf A.
dc.contributor.authorAl-Batanyeh, Khalid M.
dc.contributor.authorAl Zoubi, Mazhar S.
dc.contributor.authorAl-Trad, Bahaa
dc.contributor.authorNasef, Mohamed M.
dc.contributor.authorSatija, Saurabh
dc.contributor.authorMehta, Meenu
dc.contributor.authorPabreja, Kavita
dc.contributor.authorMishra, Vijay
dc.contributor.authorKhan, Mohammed
dc.contributor.authorAbobaker, Salem
dc.contributor.authorAzzouz, Ibrahim M.
dc.contributor.authorDureja, Harish
dc.contributor.authorPabari, Ritesh M.
dc.contributor.authorDardouri, Ashref Ali K.
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorGupta, Gaurav
dc.contributor.authorShukla, Shakti Dhar
dc.contributor.authorPrasher, Parteek
dc.contributor.authorCharbe, Nitin B.
dc.contributor.authorNegi, Poonam
dc.contributor.authorKapoor, Deepak N.
dc.contributor.authorChellappan, Dinesh Kumar
dc.contributor.authorda Silva, Mateus Webba
dc.contributor.authorThompson, Paul
dc.contributor.authorDua, Kamal
dc.contributor.authorMcCarron, Paul
dc.contributor.authorTambuwala, Murtaza M.
dc.date.accessioned2025-01-23T19:57:03Z
dc.date.available2025-01-23T19:57:03Z
dc.date.issued2020
dc.description.abstractPiceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC-BSA nanoparticles (NPs). These PIC-BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1 alpha. Our results indicate that PIC-BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1 alpha in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC-BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC-BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC-BSA NPs, enhances its therapeutic potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possible human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients.
dc.description.funderUlster University
dc.fuente.origenWOS
dc.identifier.doi10.3390/cancers12010113
dc.identifier.eissn2072-6694
dc.identifier.urihttps://doi.org/10.3390/cancers12010113
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100725
dc.identifier.wosidWOS:000516826700113
dc.issue.numero1
dc.language.isoen
dc.revistaCancers
dc.rightsacceso restringido
dc.subjectpiceatannol
dc.subjectcolon cancer
dc.subjectalbumin nanoparticles
dc.subjectnuclear P65
dc.subjectHIF-1 alpha
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAlbumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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