Modulation of Endosome Function, Vesicle Trafficking and Autophagy by Human Herpesviruses

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dc.catalogadorgrr
dc.contributor.authorTognarelli, Eduardo I.
dc.contributor.authorReyes, Antonia
dc.contributor.authorCorrales, Nicolás
dc.contributor.authorCarreño, Leandro J.
dc.contributor.authorBueno, Susan M.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorGonzález Pablo A.
dc.date.accessioned2024-01-24T23:30:51Z
dc.date.available2024-01-24T23:30:51Z
dc.date.issued2021
dc.description.abstractHuman herpesviruses are a ubiquitous family of viruses that infect individuals of all ages and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad spectrum of diseases, ranging from skin and mucosal lesions to blindness and life-threatening encephalitis, and some of them, such as Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), are known to be oncogenic. Furthermore, recent studies suggest that some herpesviruses may be associated with developing neurodegenerative diseases. These viruses can establish lifelong infections in the host and remain in a latent state with periodic reactivations. To achieve infection and yield new infectious viral particles, these viruses require and interact with molecular host determinants for supporting their replication and spread. Important sets of cellular factors involved in the lifecycle of herpesviruses are those participating in intracellular membrane trafficking pathways, as well as autophagic-based organelle recycling processes. These cellular processes are required by these viruses for cell entry and exit steps. Here, we review and discuss recent findings related to how herpesviruses exploit vesicular trafficking and autophagy components by using both host and viral gene products to promote the import and export of infectious viral particles from and to the extracellular environment. Understanding how herpesviruses modulate autophagy, endolysosomal and secretory pathways, as well as other prominent trafficking vesicles within the cell, could enable the engineering of novel antiviral therapies to treat these viruses and counteract their negative health effects.
dc.fechaingreso.objetodigital2024-01-24
dc.format.extent23 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3390/cells10030542
dc.identifier.eissn2073-4409
dc.identifier.issn2073-4409
dc.identifier.pubmedid33806291
dc.identifier.scopusidSCOPUS_ID:85103920298
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80950
dc.identifier.wosidWOS:000633489000001
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaCells
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAutophagy
dc.subjectEndocytosis
dc.subjectESCRT
dc.subjectExocytosis
dc.subjectHuman herpesviruses
dc.subjectLysosomes
dc.subjectTrans-Golgi network
dc.subjectViral
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleModulation of Endosome Function, Vesicle Trafficking and Autophagy by Human Herpesviruses
dc.typeartículo de revisión
dc.volumen10
sipa.trazabilidadORCID;2024-01-15
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