Interactions of the antiviral and antiparkinson agent amantadine with lipid membranes and human erythrocytes

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dc.contributor.authorSuwalsky, Mario
dc.contributor.authorJemiola Rzeminska, Malgorzata
dc.contributor.authorAltamirano, Mariella
dc.contributor.authorVillena, Fernando
dc.contributor.authorDukes, Nathan
dc.contributor.authorStrzalka, Kazimierz
dc.date.accessioned2024-01-10T13:49:33Z
dc.date.available2024-01-10T13:49:33Z
dc.date.issued2015
dc.description.abstractAimed to better understand the molecular mechanisms of its interactions with cell membranes, human erythrocyte and molecular models of the red cell membrane were utilized. The latter consisted of bilayers of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), representative of phospholipid classes located in the outer and inner monolayers of the human erythrocyte membrane, respectively. The capacity of amantadine to perturb the bilayer structures of DMPC and DMPE was evaluated by X-ray diffraction, fluorescence spectroscopy and differential scanning calorimetry (DSC). In an attempt to further elucidate its effects on cell membranes, the present work also examined amantadine influence on the morphology of intact human erythrocytes by means of scanning electron microscopy (SEM). Results indicated that amantadine induced morphological changes to human erythrocytes and interacted in a concentration-dependent manner with DMPC bilayers in contrast to DMPE that was hardly affected by the presence of the drug. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.funderFONDECYT
dc.description.funderEuropean Regional Development Fund
dc.fechaingreso.objetodigital21-03-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bpc.2015.04.002
dc.identifier.eissn1873-4200
dc.identifier.issn0301-4622
dc.identifier.pubmedidMEDLINE:25899993
dc.identifier.urihttps://doi.org/10.1016/j.bpc.2015.04.002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79460
dc.identifier.wosidWOS:000355358600002
dc.information.autorucMedicina;Dukes N;S/I;194143
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final20
dc.pagina.inicio13
dc.publisherELSEVIER SCIENCE BV
dc.revistaBIOPHYSICAL CHEMISTRY
dc.rightsacceso restringido
dc.subjectAmantadine
dc.subjectErythrocyte membrane
dc.subjectPhospholipid bilayer
dc.subjectPHASE-TRANSITIONS
dc.subjectIN-VITRO
dc.subjectMOLECULAR-MODELS
dc.subjectBILAYER
dc.subjectBEHAVIOR
dc.subjectHYDROCHLORIDE
dc.subjectLOCALIZATION
dc.subjectMECHANISM
dc.subjectDRUGS
dc.subjectCELLS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInteractions of the antiviral and antiparkinson agent amantadine with lipid membranes and human erythrocytes
dc.typeartículo
dc.volumen202
sipa.codpersvinculados194143
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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