Meaning in life in patients with advanced cancer: a multinational study

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dc.contributor.authorGravier, Anna L.
dc.contributor.authorShamieh, Omar
dc.contributor.authorPaiva, Carlos Eduardo
dc.contributor.authorPerez-Cruz, Pedro Emilio
dc.contributor.authorMuckaden, Mary Ann
dc.contributor.authorPark, Minjeong
dc.contributor.authorBruera, Eduardo
dc.contributor.authorHui, David
dc.date.accessioned2025-01-23T19:51:07Z
dc.date.available2025-01-23T19:51:07Z
dc.date.issued2020
dc.description.abstractBackground Few studies have examined meaning in life, a novel existential outcome, in patients with advanced cancer across countries. Objectives We examined differences in meaning in life across 5 countries and identified factors associated with meaning in life. Methods This is a pre-planned secondary analysis of a prospective longitudinal multicenter observational study of patients with advanced cancer. Meaning in life was assessed using a validated scale which examined four domains of meaning: values, purpose, goals, and reflection. The total score ranged from 8 to 32, with a higher score indicating greater meaning in life. Results Among 728 patients, the median meaning in life score was 25/32 (interquartile range 23, 28). There was no significant difference in the total meaning in life score among 5 countries (P = 0.11), though there were differences in domain sub-scores. In the univariate analysis, patients with higher intensity of physical symptoms by ESAS score (pain, fatigue, drowsiness, dyspnea, insomnia), depression, anxiety, spiritual pain, and financial distress had significantly lower meaning in life. However, patients with higher levels of education, who were married, and who had higher optimism had significantly higher meaning in life. In the multivariate analysis, higher total meaning in life scores were significantly associated with greater optimism (multivariate estimate = 0.33,p < 0.001), lower depression (- 0.26, < 0.001), spiritual pain (- 0.19, < 0.001), and financial distress (- 0.16, < 0.001). Conclusion Country of origin was not a determinant of meaning in life. However, meaning in life was significantly associated with optimism, depression, spiritual pain, and financial distress, underscoring the multidimensional nature of this construct and potential opportunities for improvement in addressing meaning in life of patients with advanced cancer.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00520-019-05239-5
dc.identifier.eissn1433-7339
dc.identifier.issn0941-4355
dc.identifier.urihttps://doi.org/10.1007/s00520-019-05239-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100568
dc.identifier.wosidWOS:000543089300049
dc.issue.numero8
dc.language.isoen
dc.pagina.final3934
dc.pagina.inicio3927
dc.revistaSupportive care in cancer
dc.rightsacceso restringido
dc.subjectCultural diversity
dc.subjectFinancial support
dc.subjectNeoplasms
dc.subjectPsychological stress
dc.subjectPalliative care
dc.subjectSpirituality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMeaning in life in patients with advanced cancer: a multinational study
dc.typeartículo
dc.volumen28
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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