Down-regulation of endothelial adhesion molecules and leukocyte adhesion by treatment with superoxide dismutase is beneficial in chronic immune experimental colitis

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dc.contributor.authorSegui, J
dc.contributor.authorGil, F
dc.contributor.authorGironella, M
dc.contributor.authorAlvarez, M
dc.contributor.authorGimeno, M
dc.contributor.authorCoronel, P
dc.contributor.authorClosa, D
dc.contributor.authorPique, JM
dc.contributor.authorPanes, J
dc.date.accessioned2024-01-10T12:04:58Z
dc.date.available2024-01-10T12:04:58Z
dc.date.issued2005
dc.description.abstractModulation of adhesion molecule expression that govern trafficking of leukocytes into the inflamed intestine is envisioned as a new strategy for treatment of inflammatory bowel disease (IBD). This study was designed to determine the impact of reducing oxidative stress on adhesion molecules expression and leukocyte recruitment in experimental chronic colitis. For that purpose, colitic interleukin-10 knockout and wild-type mice were studied. Groups of animals were treated with Cu/Zn superoxide dismutase (SOD1) 13 mg/kg/d or vehicle for either 7 or 14 days. Expression of vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1 were determined; leukocyte-endothelial cell interactions in colonic venules were studied with intravital microscopy; and changes in colon pathology and biomarkers of colitis severity were determined. Development of colitis was associated with a marked increase in endothelial vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1 expression, which were significantly reduced by treatment with SOD1 The increase in leukocyte rolling and adhesion in colonic venules of colitic mice were significantly reduced by administration of SOD1 This treatment markedly reduced colonic lipid hydroperoxidation, myeoloperoxidase activity, and plasma levels of serum amyloid A protein and resulted in significant, although modest, reductions in histologic damage score. The therapeutic value of SOD1 when administered prophylactically was assessed in the dextran sulfate sodium model of colitis with similar positive results. These results indicate that SOD1 affords significant amelioration of colonic inflammatory changes in experimental colitis. Down-regulation of adhesion molecule expression, reduction of lipid hydroperoxidation, and recruitment of leukocytes into the inflamed intestine contribute to this beneficial effect.
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/01.MIB.0000183420.25186.7a
dc.identifier.eissn1536-4844
dc.identifier.issn1078-0998
dc.identifier.pubmedidMEDLINE:16189416
dc.identifier.urihttps://doi.org/10.1097/01.MIB.0000183420.25186.7a
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75921
dc.identifier.wosidWOS:000232282100003
dc.information.autorucMedicina;Álvarez M;S/I;6131
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final882
dc.pagina.inicio872
dc.publisherOXFORD UNIV PRESS INC
dc.revistaINFLAMMATORY BOWEL DISEASES
dc.rightsacceso restringido
dc.subjectinflammatory bowel diseases
dc.subjectmucosal addressin cell adhesion molecule-1
dc.subjectoxidative stress
dc.subjectsuperoxide dismutase
dc.subjectvascular cell adhesion molecule-1
dc.subjectREACTIVE OXYGEN METABOLITES
dc.subjectINFLAMMATORY BOWEL-DISEASE
dc.subjectNF-KAPPA-B
dc.subjectACTIVE CROHNS-DISEASE
dc.subjectCELL-ADHESION
dc.subjectINTERLEUKIN-10-DEFICIENT MICE
dc.subjectMATRIX METALLOPROTEINASES
dc.subjectLYMPHOCYTE MIGRATION
dc.subjectULCERATIVE-COLITIS
dc.subjectACUTE-PANCREATITIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDown-regulation of endothelial adhesion molecules and leukocyte adhesion by treatment with superoxide dismutase is beneficial in chronic immune experimental colitis
dc.typeartículo
dc.volumen11
sipa.codpersvinculados6131
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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