Structural Evaluation by the Finite-Element Method of Hollow Microneedle Geometries for Drug Delivery

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dc.contributor.authorHenriquez, Francisco
dc.contributor.authorMorales-Ferreiro, Jorge Osvaldo
dc.contributor.authorCelentano, Diego
dc.date.accessioned2025-01-20T21:06:33Z
dc.date.available2025-01-20T21:06:33Z
dc.date.issued2022
dc.description.abstractHerein, the structural comparison, using the finite-element method (FEM), of different designs of individual hollow microneedles (MNs) is exposed, that is, conical, pyramidal, traditional, and sting type, for use as a transdermal drug delivery system (TDDS). These configurations attract interest in fields such as pharmaceutics and medicine due to their efficiency, easy administration of drugs, and significant reduction in pain compared to the traditional use of hypodermic needles. For the structural analysis and comparison of the proposed designs, ANSYS FEM-based software is used to simulate the insertion of an MN in the skin. The study and comparison are carried out under simulations of structural resistance, buckling analysis, and behavior in the MN-skin contact. The application forces are set according to the fracture resistance of the outside layer of the skin. A force of 0.16N for a conical MN is finally obtained as a critical application load to avoid a structural failure in the insertion of the MN in the human skin. Moreover, the use of poly(lactic-co-glycolic) acid (PLGA) is also assessed as a second biocompatible alternative due to both its easy handling for manufacture process and the resistance it presents in indentation simulations in which the applied force reaches 0.19N.
dc.description.funderUniversidad de Talca
dc.fuente.origenWOS
dc.identifier.doi10.1002/adem.202200049
dc.identifier.eissn1527-2648
dc.identifier.issn1438-1656
dc.identifier.urihttps://doi.org/10.1002/adem.202200049
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93355
dc.identifier.wosidWOS:000806255400001
dc.issue.numero10
dc.language.isoen
dc.revistaAdvanced engineering materials
dc.rightsacceso restringido
dc.subjectdesign
dc.subjecthollow microneedles
dc.subjectinsertion force
dc.subjectsimulation
dc.subjectskin
dc.subjectstructural analysis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStructural Evaluation by the Finite-Element Method of Hollow Microneedle Geometries for Drug Delivery
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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