Modelling Gibberella fujikuroi growth and GA(3) production in solid-state fermentation

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dc.contributor.authorGelmi, C
dc.contributor.authorPerez Correa, R
dc.contributor.authorAgosin, E
dc.date.accessioned2024-01-10T12:06:42Z
dc.date.available2024-01-10T12:06:42Z
dc.date.issued2002
dc.description.abstractA simple differential equation model was developed to represent the growth and production of a secondary metabolite in solid-state cultivation (SSC) under conditions of limited nitrogen. The model was used to interpret data obtained from SSCs of the fungus Gibberella fujikuroi, under different temperatures (25 and 31 degreesC) and water activity conditions (0.985, 0.992, 0.999). The model was calibrated in two steps. An innovative procedure to achieve good initial guesses for key parameters, such as maintenance coefficients and death rates was first applied. These initial guesses were then used in a non-linear optimisation routine to get a minimum least squares fit for the model. The mathematical model was able to reproduce the measured variables: biomass, urea, starch, CO2, O-2 and GA(3) satisfactorily. Moreover. the model indicated that the fungus does not assimilate the nitrogen source, urea, directly. The model will be useful in developing optimal feeding policies and on-line biomass estimators. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0032-9592(01)00314-4
dc.identifier.eissn1873-3298
dc.identifier.issn1359-5113
dc.identifier.urihttps://doi.org/10.1016/S0032-9592(01)00314-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76196
dc.identifier.wosidWOS:000174665200013
dc.information.autorucIngeniería;Agosin E;S/I;99630
dc.information.autorucIngeniería;Pérez J;S/I;100130
dc.issue.numero9
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1040
dc.pagina.inicio1033
dc.publisherELSEVIER SCI LTD
dc.revistaPROCESS BIOCHEMISTRY
dc.rightsacceso restringido
dc.subjectconfidence intervals
dc.subjectinert support
dc.subjectgibberellins
dc.subjectparameter estimation
dc.subjectsecondary metabolite
dc.subjecturea
dc.subjectACID PRODUCTION
dc.subjectFILAMENTOUS FUNGI
dc.subjectSUBSTRATE
dc.subjectCULTIVATION
dc.subjectKINETICS
dc.subject.ods12 Responsible Consumption and Production
dc.subject.ods07 Affordable and Clean Energy
dc.subject.odspa12 Producción y consumo responsable
dc.subject.odspa07 Energía asequible y no contaminante
dc.titleModelling Gibberella fujikuroi growth and GA(3) production in solid-state fermentation
dc.typeartículo
dc.volumen37
sipa.codpersvinculados99630
sipa.codpersvinculados100130
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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