What causes pre-eclampsia?

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dc.contributor.authorSalas, SP
dc.date.accessioned2024-01-10T13:09:57Z
dc.date.available2024-01-10T13:09:57Z
dc.date.issued1999
dc.description.abstractPre-eclampsia remains a leading cause of maternal and fetal morbidity and mortality. Despite extensive research, the mechanisms that cause pre-eclampsia are unknown and it has been considered to be. the 'disease of theories'. Hippocrates wrote in one of his Aphorisms that 'convulsions take place from either repletion or depletion'. Since then, obstetricians have been divided on the question of which factor accounted for the convulsions observed during childbirth. Some considered that a sudden reduction in intraabdominal pressure at delivery led to a pooling of blood diverted from the brain, causing collapse of the cerebral blood vessels and convulsions. Others postulated that cerebral congestion, secondary to compression of the abdominal organs by the large uterus, diverted blood to the brain, causing eclamptic convulsions. it is the purpose of this review to examine those theories about the cause of pre-eclampsia for which modern evidence is available. At present, it is believed that the pathological chain of events leading to preeclampsia is scheduled in two steps: an absolute or relative placental ischaemia is followed by a diffuse endothelial cell activation, which causes the clinical features of the disease.
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent17 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1053/beog.1999.0005
dc.identifier.issn1521-6934
dc.identifier.pubmedidMEDLINE:10746092
dc.identifier.urihttps://doi.org/10.1053/beog.1999.0005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77724
dc.identifier.wosidWOS:000082282300005
dc.information.autorucMedicina;Salas SP;S/I;51518
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final57
dc.pagina.inicio41
dc.publisherBAILLIERE TINDALL
dc.revistaBEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY
dc.rightsacceso restringido
dc.subjectpre-eclampsia
dc.subjectplacenta
dc.subjecttrophoblast
dc.subjectendothelial cell activation
dc.subjectimmune response
dc.subjectoxygen free radicals
dc.subjectgenetic predisposition
dc.subjectPREGNANCY-INDUCED-HYPERTENSION
dc.subjectNITRIC-OXIDE SYNTHESIS
dc.subjectINTRAUTERINE GROWTH-RETARDATION
dc.subjectLIPID PEROXIDES
dc.subjectENDOTHELIAL-CELLS
dc.subjectANTIPHOSPHOLIPID ANTIBODIES
dc.subjectBIOCHEMICAL-EVIDENCE
dc.subjectSEXUAL COHABITATION
dc.subjectVITAMIN-E
dc.subjectPREECLAMPSIA
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleWhat causes pre-eclampsia?
dc.typeartículo
dc.volumen13
sipa.codpersvinculados51518
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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