Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile

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dc.catalogadorgjm
dc.contributor.authorBeltrán Pavez, Carolina
dc.contributor.authorRiquelme Barrios, Sebastián
dc.contributor.authorOyarzún Arrau, Aarón
dc.contributor.authorGaete Argel, Aracelly
dc.contributor.authorGonzález Stegmaier, Roxana
dc.contributor.authorCereceda Solis, Karina
dc.contributor.authorAguirre, Adam
dc.contributor.authorTravisany, Dante
dc.contributor.authorPalma Vejares, Ricardo
dc.contributor.authorBarriga, Gonzalo P.
dc.contributor.authorGaggero, Aldo
dc.contributor.authorMartínez Valdebenito, Constanza
dc.contributor.authorLe Corre Pérez, Monique Nicole
dc.contributor.authorFerrés, Marcela
dc.contributor.authorBalcells Marty, María Elvira
dc.contributor.authorFernández, Jorge
dc.contributor.authorRamírez, Eugenio
dc.contributor.authorVillarroel, Franz
dc.contributor.authorValiente Echeverría, Fernando
dc.contributor.authorSoto Rifo, Ricardo
dc.date.accessioned2021-08-10T16:00:23Z
dc.date.available2021-08-10T16:00:23Z
dc.date.issued2021
dc.description.abstractChile has one of the worst numbers worldwide in terms of SARS-CoV-2 positive cases and COVID-19-related deaths per million inhabitants; thus, characterization of neutralizing antibody (NAb) responses in the general population is critical to understanding of immunity at the local level. Given our inability to perform massive classical neutralization assays due to the scarce availability of BSL-3 facilities in the country, we developed and fully characterized an HIV-based SARS-CoV-2 pseudotype, which was used in a 96-well plate format to investigate NAb responses in samples from individuals exposed to SARS-CoV-2 or treated with convalescent plasma. We also identified samples with decreased or enhanced neutralization activity against the D614G spike variant compared with the wild type, indicating the relevance of this variant in host immunity. The data presented here represent the first insights into NAb responses in individuals from Chile, serving as a guide for future studies in the country.
dc.fechaingreso.objetodigital2023-11-07
dc.fuente.origenConveris
dc.identifier.converisid1
dc.identifier.doi10.1126/sciadv.abe6855
dc.identifier.issn2375-2548
dc.identifier.scopusid000617708700035
dc.identifier.urihttps://www.science.org/doi/10.1126/sciadv.abe6855
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75241
dc.identifier.wosidWOS:000617708700035
dc.information.autorucEscuela de Medicina; Martínez Valdebenito, Constanza; S/I; 1007539
dc.information.autorucEscuela de Medicina; Le Corre Pérez, Monique Nicole; 0000-0002-9361-4049; 6737
dc.information.autorucEscuela de Medicina; Ferrés, Marcela; 0000-0001-9415-4657; 66180
dc.information.autorucEscuela de Medicina; Balcells Marty, María Elvira; 0000-0002-7223-9665; 7462
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaScience Advances
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInsights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile
dc.typeartículo
dc.volumen7
sipa.codpersvinculados1007539
sipa.codpersvinculados6737
sipa.codpersvinculados66180
sipa.codpersvinculados7462
sipa.indexScopus
sipa.indexWoS
sipa.trazabilidadConveris;20-07-2021
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