Cortical Oscillatory Activity Is Critical for Working Memory as Revealed by Deficits in Early-Onset Schizophrenia

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dc.contributor.authorHaenschel, Corinna
dc.contributor.authorBittner, Robert A.
dc.contributor.authorWaltz, James
dc.contributor.authorHaertling, Fabian
dc.contributor.authorWibral, Michael
dc.contributor.authorSinger, Wolf
dc.contributor.authorLinden, David E. J.
dc.contributor.authorRodriguez, Eugenio
dc.date.accessioned2024-01-10T12:38:12Z
dc.date.available2024-01-10T12:38:12Z
dc.date.issued2009
dc.description.abstractImpairments in working memory (WM) are a core cognitive deficit in schizophrenia. Neurophysiological models suggest that deficits during WM maintenance in schizophrenia may be explained by abnormalities in the GABAergic system, which will lead to deficits in high-frequency oscillations. However, it is not yet clear which of the three WM phases (encoding, maintenance, retrieval) are affected by dysfunctional oscillatory activity. We investigated the relationship between impairments in oscillatory activity in a broad frequency range (3-100 Hz) and WM load in the different phases of WM in 14 patients with early-onset schizophrenia and 14 matched control participants using a delayed matching to sample paradigm.
dc.description.abstractDuring encoding, successful memorization was predicted by evoked theta, alpha, and beta oscillatory activity in controls. Patients showed severe reductions in the evoked activity in these frequency bands. During early WM maintenance, patients showed a comparable WM load-dependent increase in induced alpha and gamma activity to controls. In contrast, during the later maintenance phase, patients showed a shift in the peak of induced gamma activity to the lower WM load conditions. Finally, induced theta and gamma activity were reduced in patients during retrieval.
dc.description.abstractOur findings suggest that the WM deficit in schizophrenia is associated with impaired oscillatory activity during all phases of the task and that the cortical storage system reaches its capacity limit at lower loads. Inability to maintain oscillatory activity in specific frequency bands could thus result in the information overload that may underlie both cognitive deficits and psychopathological symptoms of schizophrenia.
dc.description.funderBundesministeriums fur Bildung und Forschung
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1523/JNEUROSCI.1428-09.2009
dc.identifier.issn0270-6474
dc.identifier.pubmedidMEDLINE:19641111
dc.identifier.urihttps://doi.org/10.1523/JNEUROSCI.1428-09.2009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77002
dc.identifier.wosidWOS:000268444100008
dc.information.autorucPsicología;Rodríguez E;S/I;65567
dc.issue.numero30
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final9489
dc.pagina.inicio9481
dc.publisherSOC NEUROSCIENCE
dc.revistaJOURNAL OF NEUROSCIENCE
dc.rightsregistro bibliográfico
dc.subjectGAMMA-BAND RESPONSE
dc.subjectCOGNITIVE REMEDIATION THERAPY
dc.subjectRANDOMIZED CONTROLLED-TRIAL
dc.subjectBRAIN ACTIVITY
dc.subject1ST-EPISODE SCHIZOPHRENIA
dc.subjectTHETA OSCILLATIONS
dc.subjectNEURAL SYNCHRONY
dc.subjectHUMAN EEG
dc.subjectDYSFUNCTION
dc.subjectALPHA
dc.titleCortical Oscillatory Activity Is Critical for Working Memory as Revealed by Deficits in Early-Onset Schizophrenia
dc.typeartículo
dc.volumen29
sipa.codpersvinculados65567
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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