Receptores beta adrenérgicos en linfocitos circulantes de pacientes con insuficiencia cardiaca crónica

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dc.catalogadoraba
dc.contributor.authorGuarda E.
dc.contributor.authorCorbalan R.
dc.contributor.authorLavandero S.
dc.contributor.authorMartínez S.
dc.contributor.authorOcaranza, María Paz
dc.contributor.authorSapag-Hagar M.
dc.contributor.authorCasanegra P.
dc.contributor.authorValenzuela C.
dc.date.accessioned2024-06-10T21:25:32Z
dc.date.available2024-06-10T21:25:32Z
dc.date.issued1990
dc.description.abstractSevere decompensated chronic heart failure is associated to increased levels of circulating catecholamines and decreased density of myocardial beta-adrenergic receptors. In 14 patients with stable, class II-III heart failure we studied circulating lymphocytes to determine the number of beta adrenergic receptors, the dissociation constant of 3H dihydroalprenolol (kd) and the intracellular content of cyclic AMP (AMPc). Results (mean +/- SEM) were compared to those obtained in 10 healthy controls. The number of beta receptors was significantly decreased (105 +/- 16 vs 185 +/- 24, fmol/mg of membrane protein, p less than 0.01). No differences were found in Kd (1.65 +/- 0.2 vs. 1.36 +/- 0.28 nm) nor the level of AMPc (7.9 +/- 2.1 vs 7.1 +/- 2.9 pmol/mg protein), respectively. The decreased number of beta adrenergic receptors in the circulating lymphocytes may be related to the increased level of circulating catecholamines that have been shown to be present during exercise in these patients.
dc.format.extent5 páginas
dc.fuente.origenScopus
dc.fuente.origenORCID
dc.identifier.issn0034-9887
dc.identifier.pubmedid1663648
dc.identifier.scopusidSCOPUS_ID:17544403458
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86711
dc.information.autorucEscuela de Medicina; Ocaranza, María Paz; 0000-0002-4915-6378; 1001254
dc.issue.numero6
dc.language.isoen
dc.pagina.final621
dc.pagina.inicio617
dc.revistaRevista Médica de Chile
dc.rightsacceso restringido
dc.subjectMedicine
dc.subjectCardiovascular system
dc.subjectHeart failure
dc.subjectLymphocytes
dc.subjectAdrenergic receptors
dc.subjectCatecholamines
dc.subjectImmunology
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleReceptores beta adrenérgicos en linfocitos circulantes de pacientes con insuficiencia cardiaca crónica
dc.title.alternativeBeta adrenergic receptors in circulating lymphocytes of patients with chronic heart failure
dc.typeartículo
dc.volumen118
sipa.trazabilidadORCID;2024-06-03
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