Three-year incidence and acute setting predictors of epilepsy after neonatal and childhood arterial ischaemic stroke: a disease-based cohort study
dc.catalogador | grr | |
dc.contributor.author | López Espejo, Mauricio Alejandro | |
dc.contributor.author | Skorin Barriga, Ilona Stefania | |
dc.contributor.author | Mesa Latorre, Manuel Tomás | |
dc.contributor.author | Hernandez Chavez, Marta Isabel | |
dc.date.accessioned | 2024-01-11T18:08:55Z | |
dc.date.available | 2024-01-11T18:08:55Z | |
dc.date.issued | 2024 | |
dc.description.abstract | To assess the association between clinical and MRI characteristics of arterial ischaemic stroke (AIS) and the 3-year risk of post-stroke epilepsy (PSE) in paediatric patients. Retrospective cohort study. Database from a single tertiary referral centre for paediatric stroke in Chile. Two hundred seven neonates and children (1 day to 18 years) with a first-ever supratentorial AIS diagnosed between January 2003 and December 2019 were evaluated. Diagnosis of PSE and explanatory variables were consecutively recorded from hospital inpatient and annual outpatient records in a predesigned database. Competing risk analysis (competing events: death and loss to follow-up) of multiple Cox proportional hazards regression was performed to estimate adjusted subhazard ratios (SHRs) of PSE. Confidence intervals (95% CI) were calculated using bootstrap resampling (1000 replications). Interaction terms were added to investigate moderating effects. The 3-year incidence rate of PSE was 166.5 per 1000 person-years (neonatal: 150.1; childhood: 173.9). The 3-year cumulative incidence was 33%. Patients with acute symptomatic non-status seizures (SHR = 3.13; 95% CI = 1.43–6.82), status epilepticus (SHR = 5.16; 95% CI = 1.90–13.96), abnormal discharge neurological status (SHR = 2.52; 95% CI = 1.12–5.63), cortical lesions (SHR = 2.93; 95% CI = 1.48–5.81), and multifocal infarcts with stroke size < 5% of supratentorial brain volume (SHR = 3.49; 95% CI = 1.44–8.46) had a higher risk of PSE.Conclusion: This study identified specific and reliable acute clinical and imaging predictors of PSE in paediatric patients, helping clinicians identify high-risk patients with potential implications for treatment decisions. | |
dc.fuente.origen | ORCID-ene24 | |
dc.identifier.doi | 10.1007/s00431-023-05384-4 | |
dc.identifier.pubmedid | 38170290 | |
dc.identifier.uri | https://doi.org/10.1007/s00431-023-05384-4 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/80423 | |
dc.identifier.wosid | WOS:001135576100001 | |
dc.information.autoruc | Escuela de Medicina; López Espejo, Mauricio Alejandro; 0000-0003-4278-9188; 209731 | |
dc.information.autoruc | Escuela de Medicina; Skorin Barriga, Ilona Stefania; S/I; 142515 | |
dc.information.autoruc | Escuela de Medicina; Mesa Latorre, Manuel Tomás; S/I; 54102 | |
dc.information.autoruc | Escuela de Medicina; Hernandez Chavez, Marta Isabel; 0000-0992-4238-8969; 55673 | |
dc.language.iso | en | |
dc.nota.acceso | Contenido parcial | |
dc.revista | European Journal of Pediatrics | |
dc.rights | acceso restringido | |
dc.subject | Epilepsy | |
dc.subject | Stroke | |
dc.subject | Children | |
dc.subject | Competing risk | |
dc.subject | Children | |
dc.subject.ddc | 610 | |
dc.subject.dewey | Medicina y salud | es_ES |
dc.subject.ods | 03 Good health and well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | Three-year incidence and acute setting predictors of epilepsy after neonatal and childhood arterial ischaemic stroke: a disease-based cohort study | |
dc.type | artículo | |
sipa.codpersvinculados | 209731 | |
sipa.codpersvinculados | 142515 | |
sipa.codpersvinculados | 54102 | |
sipa.codpersvinculados | 55673 | |
sipa.trazabilidad | ORCID;2024-01-15 |
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