Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report

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dc.contributor.authorNavarrete-Dechent, Cristian
dc.contributor.authorMonnier, Jilliana
dc.contributor.authorMarghoob, Nadeem G.
dc.contributor.authorLiopyris, Konstantinos
dc.contributor.authorBusam, Klaus J.
dc.contributor.authorFrancis, Jasmine H.
dc.contributor.authorMarghoob, Ashfaq A.
dc.date.accessioned2025-01-20T23:50:55Z
dc.date.available2025-01-20T23:50:55Z
dc.date.issued2021
dc.description.abstractBilateral diffuse uveal melanocytic proliferation (B-DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B-DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro-gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B-DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear-cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with `B-DUMP'. Simultaneously, she developed multifocal bilateral bluish-greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. We propose that the clinical and histopathologic cutaneous findings seen in patients with B-DUMP be termed 'diffuse integumentary melanocytic proliferation (DIMP)'.
dc.description.funderNational Cancer Institute/National Institutes of Health
dc.fuente.origenWOS
dc.identifier.doi10.1111/ajd.13617
dc.identifier.eissn1440-0960
dc.identifier.issn0004-8380
dc.identifier.urihttps://doi.org/10.1111/ajd.13617
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94747
dc.identifier.wosidWOS:000648991900001
dc.issue.numero3
dc.language.isoen
dc.pagina.final389
dc.pagina.inicio386
dc.revistaAustralasian journal of dermatology
dc.rightsacceso restringido
dc.subjectbilateral diffuse uveal melanocytic proliferation
dc.subjectcancer
dc.subjectdermatology
dc.subjectocular
dc.subjectparaneoplastic syndrome
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report
dc.typeartículo
dc.volumen62
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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