Arterial pressure-flow relationship in patients undergoing cardiopulmonary bypass

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dc.contributor.authorUrzua, J
dc.contributor.authorMeneses, G
dc.contributor.authorFajardo, C
dc.contributor.authorLema, G
dc.contributor.authorCanessa, R
dc.contributor.authorSacco, CM
dc.contributor.authorMedel, J
dc.contributor.authorVergara, ME
dc.contributor.authorIrarrazaval, M
dc.contributor.authorMoran, S
dc.date.accessioned2024-01-10T13:11:14Z
dc.date.available2024-01-10T13:11:14Z
dc.date.issued1997
dc.description.abstractWe determined the arterial pressure-flow relationship experimentally by means of step changes of blood flow in 30 adult patients undergoing cardiopulmonary bypass (CPB). Anesthesia technique was uniform. CPB was nonpulsatile; hypothermia to 25-28 degrees C, and hemodilution to 18%-25% hematocrit were used. During stable bypass, mean arterial pressure was recorded first with blood flow 2.2 L.min(-1).min(-2). Flow was then increased to 2.9 L.min(-1).m(-2) for 10 s and reverted to baseline for 1 min. Then it was decreased to 1.45 L.min(-1).m(-2) for 10 s, and reverted to baseline for 1 min. Subsequently, it was decreased to 0.73 L.min(-1).m(-2) for 10 s and then reverted to baseline. line. Similar sets of measurements were repeated after 0.25 mg of phenylephrine and once the patient was rewarmed. The pressure-flow function was individually determined by regression, and the critical pressure estimated by extrapolation to zero flow. All patients had zero-flow critical pressure during hypothermia, with a mean value of 21.8 +/- 6.4 mm Hg (range 8.8-38.9). It increased after 0.25 mg phenylephrine to 25.4 +/- 7.2 mm Hg (range 12.2-43.9, P < 0.001). During normothermia, critical pressure was 21.2 +/- 5 mm Hg (range 13.4-30.9), not significantly different from hypothermia. During hypothermia, the slope of the pressure-flow function (i.e., resistance) was 14.9 +/- 3.5 mm Hg.L-1.min(-1).m(-2) (range 7.6-22.1). It increased significantly (P < 0.001) after phenylephrine, to 19.7 +/- 6.2 mm Hg.L-1.min(-1).m(-2) (range 11.4-40.5), and returned to 15.4 +/- 3.4 mm Hg.L-1.min(-1).m(-2) (range 10.1-24.2) during normothermic bypass. Systemic vascular resistance appeared to vary reciprocally with blood flow, although this finding may represent a mathematical artifact, which can be avoided by using zero-flow critical pressure in the vascular resistance equation.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00000539-199705000-00003
dc.identifier.issn0003-2999
dc.identifier.pubmedidMEDLINE:9141915
dc.identifier.urihttps://doi.org/10.1097/00000539-199705000-00003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78018
dc.identifier.wosidWOS:A1997WW54700004
dc.information.autorucMedicina;Canessa R;S/I;55800
dc.information.autorucMedicina;Irarrázaval M;S/I;98706
dc.information.autorucMedicina;Lema G;S/I;99835
dc.information.autorucMedicina;Urzúa J;S/I;98495
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final963
dc.pagina.inicio958
dc.publisherWILLIAMS & WILKINS
dc.revistaANESTHESIA AND ANALGESIA
dc.rightsacceso restringido
dc.subjectVASODILATION
dc.subjectDOGS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleArterial pressure-flow relationship in patients undergoing cardiopulmonary bypass
dc.typeartículo
dc.volumen84
sipa.codpersvinculados55800
sipa.codpersvinculados98706
sipa.codpersvinculados99835
sipa.codpersvinculados98495
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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