Value of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tuberculous peritonitis - A meta-analysis

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dc.contributor.authorRiquelme, Arnoldo
dc.contributor.authorCalvo, Mario
dc.contributor.authorSalech, Felipe
dc.contributor.authorValderrama, Sebastian
dc.contributor.authorPattillo, Alejandro
dc.contributor.authorArellano, Marco
dc.contributor.authorArrese, Marco
dc.contributor.authorSoza, Alejandro
dc.contributor.authorViviani, Paola
dc.contributor.authorLetelier, Luz Maria
dc.date.accessioned2024-01-10T13:44:09Z
dc.date.available2024-01-10T13:44:09Z
dc.date.issued2006
dc.description.abstractBackground and Goals: Adenosine deaminase (ADA) levels are used for diagnosing tuberculosis in several locations and although many studies have evaluated ADA levels in ascitic fluid. These studies have defined arbitrary cut-off points creating difficulties in the clinical application of the results. The goals of this study are: to determine the usefulness of ADA levels in ascitic fluid as a diagnostic test for peritoneal tuberculosis (PTB) and define the best cut-off point.
dc.description.abstractStudy: A systematic review was done on the basis of 2 independent searches. We selected prospective studies that included consecutive patients. Diagnosis of PTB had to be confirmed by bacteriologic or histologic methods and ADA levels determined by the Giusti method. Inclusion/exclusion criteria were applied by 2 independent reviewers. A receiver operating characteristic curve was constructed to establish the optimal cut-off point and the likelihood ratios (LRs) estimated using fixed-effect pooled method.
dc.description.abstractResults: Twelve prospective studies were found. Four of them met the inclusion criteria and were thus included in the meta-analysis. They included 264 patients, of which 50 (18.9%) had PTB. ADA levels showed high sensitivity (100%) and specificity (97%) using cut-off values from 36 to 40IU/L. The included studies were homogeneous. Optimal cut-off point was determined at 39 IU/L, and LRs were 26.8 and 0.038 for values above and below this cut-off.
dc.description.abstractConclusions: This study supports the proposition that ADA determination is a fast and discriminating test for diagnosing PTB with an optimal cut-off value of 39 IU/L.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00004836-200609000-00009
dc.identifier.eissn1539-2031
dc.identifier.issn0192-0790
dc.identifier.pubmedidMEDLINE:16940883
dc.identifier.urihttps://doi.org/10.1097/00004836-200609000-00009
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78852
dc.identifier.wosidWOS:000240159900009
dc.information.autorucMedicina;Arrese M;S/I;76095
dc.information.autorucMedicina;Letelier L;S/I;52245
dc.information.autorucMedicina;Riquelme A;S/I;3538
dc.information.autorucMedicina;Soza A;S/I;461
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final710
dc.pagina.inicio705
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF CLINICAL GASTROENTEROLOGY
dc.rightsacceso restringido
dc.subjectadenosine deaminase
dc.subjectascites
dc.subjecttuberculous peritonitis
dc.subjectmeta-analysis
dc.subjectEXTRAPULMONARY TUBERCULOSIS
dc.subjectUNITED-STATES
dc.subjectSERUM
dc.subjectTOOL
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleValue of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tuberculous peritonitis - A meta-analysis
dc.typeartículo
dc.volumen40
sipa.codpersvinculados76095
sipa.codpersvinculados52245
sipa.codpersvinculados3538
sipa.codpersvinculados461
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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