A kinetic model of continuous radiation damage to populations of cells: comparison to the LQ model and application to molecular radiotherapy

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dc.contributor.authorNeira, Sara
dc.contributor.authorGago-Arias, Araceli
dc.contributor.authorGuiu-Souto, Jacobo
dc.contributor.authorPardo-Montero, Juan
dc.date.accessioned2025-01-23T19:46:51Z
dc.date.available2025-01-23T19:46:51Z
dc.date.issued2020
dc.description.abstractThe linear-quadratic (LQ) model to describe the survival of irradiated cells may be the most frequently used biomathematical model in radiotherapy. There has been an intense debate on the mechanistic origin of the LQ model. An interesting approach is that of obtaining LQ-like behavior from kinetic models, systems of differential equations that model the induction and repair of damage. Development of such kinetic models is particularly interesting for application to continuous dose rate therapies, such as molecular radiotherapy or brachytherapy. In this work, we present a simple kinetic model that describes the kinetics of populations of tumor cells, rather than lethal/sub-lethal lesions, which may be especially useful for application to continuous dose rate therapies, as in molecular radiotherapy. The multi-compartment model consists of a set of three differential equations. The model incorporates in an easy way different cross-interacting compartments of cells forming a tumor, and may be of especial interest for studying dynamics of treated tumors. In the fast dose delivery limit, the model can be analytically solved, obtaining a simple closed-form expression. Fitting of several surviving curves with both this solution and the LQ model shows that they produce similar fits, despite being functionally different. We have also investigated the operation of the model in the continuous dose rate scenario, firstly by fitting pre-clinical data of tumor response to I-131-CLR1404 therapy, and secondly by showing how damage repair and proliferation rates can cause a treatment to achieve control or not. Kinetic models like the one presented in this work may be of special interest when modeling response to molecular radiotherapy.
dc.fuente.origenWOS
dc.identifier.doi10.1088/1361-6560/aba21d
dc.identifier.eissn1361-6560
dc.identifier.issn0031-9155
dc.identifier.urihttps://doi.org/10.1088/1361-6560/aba21d
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100324
dc.identifier.wosidWOS:000597727700001
dc.issue.numero24
dc.language.isoen
dc.revistaPhysics in medicine and biology
dc.rightsacceso restringido
dc.subjectbiomathematical model
dc.subjectradiotherapy
dc.subjectkinetic models
dc.subjectlinear-quadratic
dc.subjectmolecular radiotherapy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA kinetic model of continuous radiation damage to populations of cells: comparison to the LQ model and application to molecular radiotherapy
dc.typeartículo
dc.volumen65
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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